Acute Respiratory Failure
Conditions
Keywords
Acute respiratory failure, Surface mechanomyography, Respiratory effort
Brief summary
Surface mechanomyography (sMMG) has been proposed as a tool to study muscle mechanical activity. sMMG is a noninvasive technique using specific transducers to record muscle surface oscillations due to mechanical activity of the motor units . It could be of major interest for the detection of respiratory efforts in patients with respiratory failure. This study aims at assessing the performances of sMMG to measure and detect respiratory drive and effort in healthy volunteers.
Interventions
DEVICEnon-invasive ventilation with or without resistance
non-invasive ventilation with or without resistance.
Sponsors
University Hospital, Angers
Study design
Allocation
NA
Intervention model
CROSSOVER
Primary purpose
DEVICE_FEASIBILITY
Masking
SINGLE (Outcomes Assessor)
Masking description
Recordings will be analysed by investigators blind to ventilation conditions
Intervention model description
Esophageal pressure, electrical activity of the diaphram (Eadi) and sMMG will be recorded in 10 healthy subjects in spontaneous ventilation (SV) and non-invasive ventilation with or without resistance.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy volunteer * Age \> 18 and \< 60 * Informed consent * Fasting * Subjects covered by or having the rights to medical care assurance
Exclusion criteria
* Obesity (BMI \> 30 kg.m-2) * Respiratory disease * Cardiovascular disease * Contraindication to the insertion of a nasogastric tube * Incapacity to consent * Pregnancy, breastfeeding * Bad understanding of the French language, * Other protected person according to articles L1121.7 and L1121.8 of the French Public Health Act.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of sMMG to detect respiratory effort | 5 minutes after the beginning of recording | Delays between the beginning of the respiratory effort detected by sMMG and Eadi and the end of the respiratory effort detected by sMMG and Eadi (msec) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison between sMMG-time (MMG-TP) and PTPes-Pes Peak | 5 minutes after the beginning of recording | Accuracy of sMMG to assess the intensity of respiratory effort (in comparison with pressure-time product in cm H2O.s.min-1) |
| Comparison between sMMG slope & Eadi parameters | 5 minutes after the beginning of recording | Accuracy of sMMG to assess the intensity of respiratory drive (in comparison with Eadi in microvolt) |
| Comparison between sMMG slope & slope Peso | 5 minutes after the beginning of recording | Accuracy of sMMG to assess the intensity of respiratory drive (in comparison Peso in cm H20) |
| Delay between neural time measured by sMMG and neural time measured by Eadi | 5 minutes after the beginning of recording | Accuracy of sMMG to assess the duration of inspiratory neural time (in comparison with Eadi in msec) |
Countries
France
Outcome results
None listed