Basal Cell Carcinoma, Lentigo Maligna, Melanoma, Nevus, Seborrheic Keratosis, Lentigo
Conditions
Keywords
Melanoma diagnosis, Diagnosis Imaging, Fluorescence-Advanced videodermatoscopy, Reflectance confocal microscopy, Super-high magnification dermoscopy
Brief summary
Reflectance confocal microscopy (RCM) is the reference in vivo imaging technique for identifying malignant melanocytic tumors prior to surgical excision. However, it is not widely used due to its high cost and highly technical and time-consuming nature. In addition to Reflectance confocal microscopy (RCM), it currently use 2 less expensive dermatoscopes that also allow in vivo diagnosis: super-high magnification dermoscopy (D400) and Fluorescence-Advanced videodermatoscopy (FAV).
Detailed description
Several studies have demonstrated their interest in the in vivo diagnosis of melanocytic tumors, but without any comparison between these methods. In our current practice, many patients have benefited from these 3 imaging modalities for benign and malignant lesions. Therefore, our aim is to analyze these images and compare their performance in the diagnosis of benign and malignant pigmented lesions.
Interventions
DIAGNOSTIC_TESTFluorescence-Advanced videodermatoscopy
Datas collected : Presence or absence of atypical roundish cell, dendritic cell, atypical nests, points, folliculotropism, blue homogenous zone, regular honeycomb pattern. Between 10 and 60 images taken by a hand-held camera set directly on the skin lesion, with an oily interface.
DIAGNOSTIC_TESTReflectance confocal microscopy
Datas collected : Presence or absence of atypical roundish cell, dendritic cell, atypical nests, points, folliculotropism, blue homogenous zone, regular honeycomb pattern. Between 10 and 60 images taken by a hand-held camera set directly on the skin lesion, with an oily interface.
DIAGNOSTIC_TESTSuper-high magnification dermoscopy
Datas collected : Presence or absence of atypical roundish cell, dendritic cell, atypical nests, points, folliculotropism, blue homogenous zone, regular honeycomb pattern. Between 10 and 60 images taken by a hand-held camera set directly on the skin lesion, with an oily interface.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with a pigmented skin lesion of more than 3mm diameter which have benefited systematically of all 3 imaging techniques at the same time, followed by either a surgical excision or annual imaging monitoring.
Exclusion criteria
* Bad quality images * Insufficient number of images * Uncertain diagnosis given by the pathologist * Refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare the the relevance of each technique for the diagnostic of pigmented lesions. | Day 1 | The nature of the tumor is diagnosed by the imaging technique. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of performance of imaging techniques | Day 1 | Analyze the results of imaging of each technique. |
Countries
France
Outcome results
None listed