Liver and Biliary Tract Disorders in Duration of Pregnancy, Other End-stage Liver Diseases in Children
Conditions
Brief summary
The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort. The investigators collected the demographic and clinicopathological data of donors and recipients, and determined the risk factors of early postoperative delayed recovery of hepatic function (DRHF) by univariate and multivariate Logical regression analyses.
Interventions
None listed
Sponsors
Huiwu Xing
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
0 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
1. children with the indication of LDLT \[cholestatic liver disease (such as BA), metabolic liver disease (such as Wilson's disease and Ornithine transcarbamylase deficiency), acute liver failure (such as drug induced), neoplastic disease (such as hepatoblastoma), vascular disease (such as cavernous transformation of portal vein and congenital absence of portal vein), re-transplantation and others\]; 2. the relatives of the children voluntarily donated part of the liver which met the requirements of LDLT.
Exclusion criteria
1. recipients with contraindications of LDLT (such as coagulation dysfunction, acute infection, cardiopulmonary failure); 2. failure to complete LDLT due to various reasons (such as death during or within 3 days after operation); 3. recipients or donors with incomplete necessary data.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| DRHF | 30 days after LDLT in children | Investigators collected liver function data of children after LDLT. Delayed recovery of hepatic function (DRHF) is characterized by the increase of PT-INR combined with hyperbilirubinemia on or after postoperative day 5. |
Countries
China
Outcome results
None listed