Sepsis
Conditions
Brief summary
This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.
Detailed description
All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.
Interventions
OTHERnothing
disease
Sponsors
Tianjin Nankai Hospital
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
1. Males or females over the age of 18; 2. Sepsis was diagnosed within 48h which meets SPESIS 3 criteria; 3. Capable of understanding the purpose and risk of the study; 4. Patients or proxy must give written informed consent before any assessment is performed.
Exclusion criteria
1. Pregnancy, lactation or perinatal period; 2. Breast carcinoma; 3. HIV seropositive or Syphilis seropositive; 4. Any clinical-relevant condition that might affect study participation and/or study results; 5. Participation in any other intervention trial; 6. Unwillingness or inability to following the study protocol in the investigators opinion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ADP-ribosylation factor 4, ARF4 | Up to Day 28 | ARF4 levels were measured in the PBMCs of sepsis patients and healthy controls |
| cAMP-response element binding protein 3, CREB3 | Up to Day 28 | CREB3 levels were measured in the PBMCs of sepsis patients and healthy controls |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation index | Up to Day 28 | The ratio of arterial oxygen partial pressure (PaO2 in mmHg) to fractional inspired oxygen (FiO2 expressed as a fraction, not a percentage). |
| Mechanical ventilation days | Up to Day 28 | The number of days the patient was alive and mechanical ventilating |
| Inflammation biomarkers Inflammation levels | Up to Day 28 | Procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) |
| Heme oxygnase-1, HO-1 | Up to Day 28 | HO-1 levels were measured in the PBMCs of sepsis patients and healthy controls |
| 28 days survive | Up to Day 28 | All Cause Mortality to Day 28 |
| Sequential Organ-Failure Assessment (SOFA) score | Up to Day 28 | The SOFA score is used to assess the severity and prognosis of sepsis. SOFA was based on six different scores, one for each of the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems each scored from 0 to 4 with an increasing score reflecting worsening organ dysfunction. |
| Acute Physiology and Chronic Health Evaluation II (APACHE II) score | Up to Day 28 | The APACHE II score consists of three parts: acute physiological score, age score, and chronic health score. APACHE II uses a point score (range 0 to 71) based upon initial values of 12 routine physiologic measurements, age, and previous health status to provide a general measure of severity of disease, with an increasing score reflecting worsening organ dysfunction. |
| ICU stay length | Up to Day 90 | The number of days the patient was alive and ICU stay |
| ARF family | Up to Day 28 | ARF1, ARF3, ARF5, ARF6 levels were measured in the PBMCs of sepsis patients and healthy controls |
Countries
China
Contacts
Primary ContactJianbo Yu, MD
Outcome results
None listed