BPD - Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Necrotizing Enterocolitis, Patent Ductus Arteriosus, Periventricular Leukomalacia, Sepsis
Conditions
Keywords
PUFAs
Brief summary
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic attributes of PUFAs in premature infants and their interplay with the onset of diseases. This study anticipates furnishing a theoretical foundation for the rationalization of PUFAs supplementation in premature infants and for informing strategies related to disease prevention and management.
Interventions
None listed
Sponsors
The First Hospital of Jilin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
Infants born between 24 and 36 weeks of gestational age who are admitted within 24 hours of birth, including both premature and full-term newborns. \-
Exclusion criteria
Infants with severe congenital developmental abnormalities, those requiring external supplementation of PUFAs in addition to standard intravenous nutrition and breastfeeding, and those with a severe prognosis indicating non-survival during their hospitalization. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality and severe complications of premature infants | before discharge | incidence of death，NEC，PDA，BPD，IVH，PVL and sepsis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| NEC | before discharge | Bell stage II or III |
| PDA | before discharge | confirmed by echocardiography |
| BPD | before discharge | nasal CPAP/NIPPV or invasive ventilation requirement at 36 weeks postmenstrual age or at discharge, transfer or death if before 36 weeks |
| Mortality | before discharge | death |
| PVL | before discharge | periventricular cysts on cranial ultrasound or magnetic resonance imaging |
| sepsis | before discharge | blood culture positive |
| IVH | before discharge | Papile grades 3-4 |
Outcome results
None listed