Polyneuropathies
Conditions
Keywords
polyneuropathy, biomarkers, cohort study
Brief summary
Biomarkers for prognosis of patients with polyneuropathy.
Detailed description
AIM: To investigate biomarkers' use as a prognostic tool in polyneuropathy patients. STUDY DESIGN: Prospective cohort study of patients with polyneuropathy. METHODS: 200 patients with polyneuropathy will be examined with physical tests, medical examination, questionnaires, and blood biomarkers at baseline and at 1-year follow-up, and 2-year follow-up. ANALYSIS: The investigators will calculate the odds of disease progression after 2 years depending on biomarkers levels at baseline using multiple logistic regression with sex and age adjustment. Diagnostic performance of the physical tests and biomarkers for prediction of disease progression will be assessed by Receiver Operating Characteristic Curve analysis with the area under the curve.
Interventions
None listed
Sponsors
Rigshospitalet, Denmark
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Minimum 18 years old. * Diagnosed with polyneuropathy, confirmed by nerve conduction study. * Can read and understand Danish.
Exclusion criteria
* Inability to perform physical tests due to comorbidity not associated to the patient's polyneuropathy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Disease Severity | 2 years | Primary outcome is disease severity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient Reported Outcomes (PROMs) | 2 years | Secondary outcome is patient reported outcomes. |
Countries
Denmark
Contacts
Primary ContactTina Dysgaard, Dr.med.
Outcome results
None listed