COVID-19, Sarcoidosis
Conditions
Keywords
Sarcoidosis, COVID-19, SARS-CoV-2, Granulomatous disease
Brief summary
The goal of this observational study is to learn about sarcoidosis development after COVID-19 infection. The main question it aims to answer is: * prevalence of Sarcoidosis among patients previously infected with COVID-19. Participants will: * provide previous positive RT-PCR for COVID-19 * Have computed tomography of the Chest with suggestive findings of sarcoidosis * Have bronchoscopic guided biopsies and pathological analysis to detect number of patients with sarcoidosis.
Detailed description
This prospective cross sectional study was performed on a total of 55 patients with mediastinal and /or hilar lymphadenopathy with or without lung infiltrates referred to Bronchoscopy unit , Chest department, Ain-Shams University hospital for biopsy taking and diagnosis. All patients were subjected to the following : history taking , clinical examination , radiological assessment by computed tomography (CT )chest , fiberoptic bronchoscopy where biopsies were taken either by conventional-Trans-bronchial needle aspiration (c-TBNA) , endo-bronchial ultrasound (EBUS-TBNA) or direct forceps biopsies and sent for histopathological examination and if the patient had past history of COVID-19 infection with previous positive reverse transcriptase- polymerase chain reaction assay (RT-PCR).
Interventions
PROCEDUREflexible bronchoscopy
fiberoptic bronchoscopy was done where biopsies were taken either by conventional TBNA (c-TBNA) , EBUS-TBNA or direct forceps biopsies and sent for histopathological examination
Sponsors
Ain Shams University
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All adult patients with previous positive RT-PCR for COVID -19 and CT chest findings of mediastinal and or hilar lymphadenopathy with or without lung infiltrate will be included. .
Exclusion criteria
* Patients younger than 18 years old Patients * Patients refuse to participate in the study * Patients previously diagnosed as sarcoidosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number and risk factors of sarcoidosis development after COVID -19 infection as diagnosed by TBNA guided tissue biopsies in bronchoscopy unit, chest department, Ain Shams university. | 6 months | Number of COVID-19 patients diagnosed by TBNA guided biopsies as having granulomatous tissue suggesting sarcoidosis development, and risk factors that associate its development. |
Countries
Egypt
Outcome results
None listed