Study on Doppler Ultrasound Measurement of Changes in Uterine Artery Blood Flow in Normal First Trimester Pregnancies and Its Prediction on Abortion

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06043804

Enrollment

200

Registered

2023-09-21

Start date

2023-10-01

Completion date

2026-04-30

Last updated

2023-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormal Uteroplacental Circulation

Brief summary

Objective:To explore the study of Doppler ultrasound in first trimester pregnancies to measure the change of uterine artery blood flow in normal pregnancies and the prediction on abortion, which provides a certain reference for the change trend of uterine artery blood flow in normal first trimester pregnancies and the prediction of Doppler ultrasound measurement in abortion. Method:Pregnant women who underwent natural conception and single birth prenatal examination in the Obstetrics Department of the Second Affiliated Hospital of Wenzhou Medical University from October 1, 2023 to December 31, 2025 were selected as the study population. Eligible women were preliminarily screened according to the inclusion conditions of the study objects, and basic information of women in each group was compared: Maternal age, gestational time, birth time, gestational week, abortion history, maternal BMI, maternal MAP, smoking status, serum HCG, subchorionic hematoma, fetal bradycardia, left and right uterine aorta pulse index (PI), resistance index (RI) and systolic/diastolic ratio (S/D), etc. To investigate the effect of Doppler ultrasonography on the measurement of uterine artery blood flow in normal pregnancy and the prediction of abortion.

Interventions

OTHERDoppler ultrasound measurement of changes in uterine artery blood flow

Doppler ultrasound measurement of changes in uterine artery blood flow

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

16 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

Healthy pregnant women Group Inclusion Criteria: 1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks; 2. Complete maternal clinical data;

Exclusion criteria

1. The level of chorionic gonadotropin (HCG) was static or decreased by ultrasonography; 2. multiple pregnancy; 3. Patients with congenital uterine malformations, uterine fibroids and any other uterine disease; 4. Patients who have chronic diseases or are receiving chronic treatment. Pregnant women with recurrent pregnancy loss Group Inclusion Criteria: 1. Intrauterine pregnancy sac and cardiac activity were confirmed by ultrasound examination at 6 weeks; 2. Complete maternal clinical data; 3. There has been a history of spontaneous abortion with the same sexual partner for two or more consecutive times;

Design outcomes

Primary

Measure	Time frame	Description
Pulsatility index	it can be monitored for up to 12 weeks	Pulsatility index of the left and right main uterine arteries
Resistive index	it can be monitored for up to 12 weeks	Resistive index of the left and right main uterine arteries
Systolic-to-diastolic ratio	it can be monitored for up to 12 weeks	Systolic-to-diastolic ratio of the left and right main uterine arteries

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026