Crohn Disease, Healthy, Inflammatory Bowel Diseases, Ulcerative Colitis
Conditions
Brief summary
Objective: To use clinical, genetic and genome analysis to better understand and define the genetic and environmental factors that contribute to IBD within affected populations.
Detailed description
Background: Inflammatory bowel disease (IBD) is a chronic, and often disabling, disorder of the intestines characterized by dysregulation of mucosal immune response. Recent data suggests that the incidence and prevalence rates among all populations may be increasing due to constantly changing environmental exposures. The goal of the study is to identify susceptible genes that contribute to the pathogenesis of IBD in affected individuals.
Interventions
Blood or saliva sample & clinical data collection
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mount Sinai Hospital, Canada
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined) * Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U)) * Healthy controls: no personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss * Any age
Exclusion criteria
\- Subjects with other gastrointestinal conditions not meeting the above IBD or Healthy Control criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genomics studies across populations | 2022-2027 | Whole Exome Sequencing (+/- other sequencing) is planned |
Countries
Canada
Contacts
Primary ContactJoanne Stempak, MSc
Backup ContactJenny Lee, MKin
Outcome results
None listed