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Retrospective Analysis of Pain After Nerve Block in Surgical Patients

Retrospective Analysis of Pain in Patients Who Receive a Nerve Block for Surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06042322
Enrollment
166
Registered
2023-09-18
Start date
2017-01-01
Completion date
2028-12-31
Last updated
2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Pain, Knee Osteoarthritis, Regional Anesthesia Morbidity

Brief summary

This is a retrospective study looking at patients who received a nerve block for surgery and assessing pain after the nerve block resolves, with or without an educational intervention, over two periods of time.

Detailed description

Regional anesthesia (RA) is a vital tool that can serve as the primary anesthetic or as part of a multimodal perioperative pain regimen. RA is strongly associated with decreased acute and persistent pain and opioid consumption postoperatively. However, some patients experience an acute worsening of pain into the severe range around the time of RA resolution, also known as "rebound pain" (RP). The incidence of RP has been reported as high as 40-50% after a single shot nerve block for patients undergoing ambulatory surgery. This retrospective study aims to look at patients who received a nerve block for surgery and assessing pain after the nerve block resolves in the presence and absence of certain interventions, such as a multidisciplinary educational intervention. The investigators will assess patients who received a primary total knee arthroplasty who received a single shot adductor canal nerve block, received pericapsular injection by the surgeon, and had a length of stay \> 16 hours.

Interventions

OTHEREducational intervention

Multidisciplinary educational intervention was performed by orthopedic, anesthesia, and nursing team. This included a discussion of the patient's pain plan and a patient visit.

Sponsors

Brigham and Women's Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL

Inclusion criteria

* primary total knee arthroplasty * received an adductor canal nerve block * received pericapsular injection by surgeon intraoperatively * admitted for overnight stay and \> 16 hours post-nerve block

Exclusion criteria

* age \< 18 * prior total knee arthroplasty on ipsilateral knee

Design outcomes

Primary

MeasureTime frameDescription
Difference in maximum pain score, 0-10; (0 = no pain, 10 = worst pain)6-24 hoursDifference in maximum pain score, numerical pain rating scale 0-10, 6-24 hours after nerve block between the two cohorts

Secondary

MeasureTime frameDescription
Average pain score 0-10; (0 = no pain, 10 = worst pain)6-24 hoursDifference in area under the curve of pain scores, numerical pain rating scale 0-10, 6-24 hours after nerve block between the two cohorts (educational intervention and non-educational intervention time periods)
Difference in incidence of rebound pain6-24 hoursDifference in incidence pain score ≥ 7 between 6-24 hours post nerve block between the two cohorts
Comparison of evening opioids given6-24 hoursComparison of if evening opioids were or were not given (yes/no) between the two cohorts
Difference in total opioids given6-24 hoursDifference in total opioids given (mEq of morphine) between the two cohorts
Difference in length of stay0-2 yearsDifference in length of stay (days) between the two cohorts

Contacts

PRINCIPAL_INVESTIGATORYun-Yun K Chen, MD

Brigham and Women's Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 29, 2026