Obstructive Sleep Apnea, Postoperative Complications
Conditions
Keywords
obstructive sleep apnea, postoperative pulmonary complications, general anesthesia
Brief summary
It is known that perioperative respiratory complications occur more often in obstructive sleep apnea syndrome (OSAS) patients during general anesthesia. Although there are prospective RCTs in this area, the need for further and larger studies remains due to the heterogenity of the results. Moreover, the incidence of postoperative pulmonary complications in OSAS patients undergoing surgery in Turkey and the predictive factors affecting the respiratory adverse events are uncertain. Therefore, in this prospective observational cohort study, it was aimed to determine the incidence of postoperative pulmonary complications and the predictor factors associated with patient, anesthesia and surgery in surgical patients with a confirmed or highly suspected OSAS diagnosis undergoing general anesthesia.
Interventions
PROCEDUREElective surgical procedure under general anesthesia
The incidence of postoperative pulmonary complications in OSAS patients undergoing elective surgery under general anesthesia will be determined.
Sponsors
Istanbul University - Cerrahpasa
Acibadem University
Baskent University
Celal Bayar University
Cukurova University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 18-65 years 2. ASA physical status I-III 3. Preoperative OSAS diagnosis (with polysomnography or STOP-BANG questionnaire score) 4. Surgeries performed under general anesthesia 5. Endotracheal intubation facilitated by neuromuscular blockers
Exclusion criteria
1. ASA physical status IV or V 2. Planned admission to the ICU after surgery 3. Cardiac Surgery 4. Non-operating room anesthesia 5. Neuromuscular disease 6. Emergency or re-operational procedure 7. Laryngectomy 8. Pneumonectomy 9. Invasive airway access 10. Pregnancy 11. Outpatient surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pulmonary complications | Postoperative day 1, 2, 7 and 30. | The rate of postoperative hypoxia (respiratory failure), atelectasis, pulmonary edema /embolus, aspiration, bronchospasm, respiratory infection / pneumonia, pleural effusion, pneumothorax, respiratory arrest will be measured |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Predictive factors | Postoperative day 1, 2, 7 and 30. | Determination of patient, anesthesia and surgery-related predictive factors affecting the development of postoperative pulmonary complications. |
| Non-invasive/invasive mechanical ventilation requirement | Postoperative day 1, 2, 7 and 30. | Determination of the need for non-invasive or invasive mechanical ventilation beyond clinical standards. |
| Intensive care unit admission | Postoperative day 1, 2, 7 and 30. | Intensive care unit admission for respiratory indication |
| Mortality | Postoperative day 30. | Mortality rate |
Countries
Turkey (Türkiye)
Contacts
Primary ContactÇiğdem Tütüncü, Prof. Dr.
Backup ContactDemet Laflı Tunay, Dr.
Outcome results
None listed