Functional Magnetic Resonance-Based Observations of Brain Networks in Moyamoya Disease Patients Under Anesthesia

Functional Magnetic Resonance-Based Observations of Brain Networks and Cerebrovascular Reactivity in Patients With Moyamoya Disease Under Anesthetic Sedation, A Prospective Observational Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06041659

Enrollment

Registered

2023-09-18

Start date

2023-10-24

Completion date

2025-12-31

Last updated

2025-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moyamoya Disease

Keywords

Moyamoya Disease, Cerebral Network, Cognitive Function, Anesthesia

Brief summary

Moyamoya disease is characterized by progressive stenosis of the genesis of the distal internal carotid arteries bilaterally and progressive generation of compensatory pathological vascular networks at the basis cranii, and these pathological vasculature has poor vascular reactivity. Perioperative circulatory management of patients with smoky vessels to ensure perfusion of brain tissue and integrity of brain network during surgery to minimize postoperative impairment of neurological functions, including motor, sensory, emotional and cognitive functions, is the key point of perioperative circulatory management of moyamoya disease. Functional Magnetic Resonance Imaging (fMRI) has been routinely used in various cerebrovascular diseases to further evaluate cerebrovascular reserve and cerebral network connectivity. The purpose of this study is to observe the changes in cerebral blood flow, cerebral oxygen metabolism, cerebral oxygen metabolism rate, and cerebral network connectivity in adult patients with moyamoya disease in cerebral ischemia-sensitive areas under anesthesia to provide a basis for exploring anesthesia management to improve cognitive function and cerebral network connectivity in these patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients with moyamoya disease scheduled for direct or indirect intracranial and extracranial revascularization surgery * Age between 18-65 years * Obtain written informed consent.

Exclusion criteria

* Patients with preoperative claustrophobia, sensory or motor aphasia that are unable to understand and cooperate with the examination * Preoperative cranial imaging suggesting cerebral infarction lesion diameter \>15mm * Patients allergic to anesthetic drugs * Metal implants in the body * Undergoing other experimental drug or instrumentation trials

Design outcomes

Primary

Measure	Time frame
Changes of brain functional network	Before sedation, after sedation and after maintenan the blood pressure at baseline 100%-120% for 15min

Secondary

Measure	Time frame
Postoperative delirium	Day1-5 after surgery
Electroencephalogram changes	Before sedation, after sedation and after maintenan the blood pressure at baseline 100%-120% for 15min

Countries

China

Contacts

Primary ContactShu Li

lishu@bjtth.org8613699223065

Outcome results