Pain, Postoperative
Conditions
Keywords
Ketamine, Preemptive Analgesia
Brief summary
The goal of this randomized controlled trial is to compare the effect of preemptive ketamine administration to placebo administration in patients underwent hysterectomy surgery. The main questions it aims to answer are: 1. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the duration of analgesia after hysterectomy surgery 2. To determine the effect of ketamine at a dose of 0.5 mg/kgBW as preemptive analgesia on the need for fentanyl after hysterectomy surgery
Interventions
DRUGKetamine
The intervention was prepared by the research team (anesthesia resident) in the form of ketamine which had been diluted to a dosage of 10 mg/cc, taken according to the required dose based on actual body weight then diluted with 0.9% NaCl to 10 cc. Then the two solutions were given to researchers without knowing the contents of the drugs that had been prepared by the resident who assisted in this research.
OTHERPlacebo
While the 0.9% NaCl solution was used as placebo was prepared in a 10 cc syringe
Sponsors
Universitas Padjadjaran
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Patients aged 18-50 years. 2. ASA I and II physical status (American Society of Anesthesiologists).
Exclusion criteria
1. The patient is not willing to be included as a research subject 2. The patient takes anti-pain medication before surgery 3. History of allergies to the drugs to be used 4. History of chronic pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Duration of postoperative analgesia | 24 hours post operative | Time interval from completion of hysterectomy until additional analgesic is needed, namely fentanyl 25 µg via PCA |
| Total need for post-operative analgesic rescue | 24 hours post operative | The total amount of rescue analgetic required by research subjects, during the 24 hours after surgery, was given via PCA |
Countries
Indonesia
Outcome results
None listed