Bolus vs. Continuous IV Lidocaine Against Post-Extubation Cough in Post-Thyroidectomy Patients

Comparison of Bolus Intravenous Lidocaine Administration With Continuous Intravenous Lidocaine Against Post-Extubation Cough Incidence in Post-Thyroidectomy Patients

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06040034

Enrollment

Registered

2023-09-15

Start date

2023-02-02

Completion date

2023-05-01

Last updated

2023-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cough

Brief summary

The goal of this randomized controlled trial is to compare the effect of lidocaine bolus intravenous administration to lidocaine continuous intravenous administration in post thyroidectomy patients to observe the effect against post-extubation cough. The main questions it aims to answer are: * Cough incidence on both groups * Which method is preferable to reduce post-extubation cough incidence

Interventions

DRUGLidocaine IV

Lidocaine given as bolus or continuous infusion.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Intervention model description

Comparison

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* ASA class 1 and 2 * Thyroidectomy patients in Hasan Sadikin Bandung Hospital

Exclusion criteria

* Subjects' refusal * Had history of drug allergy, specifically lidaocaine * Had history of asthma or other lung diseases * Active smoker * History of arrhythmia * Bradycardia subjects (\<60 beats per minute) * Pregnant people * Perioperative upper respiratory tract infusion * Routinely consume ACE inhibitor / bronchodilators / steroid * Renal dysfunction * Liver dysfunction

Design outcomes

Primary

Measure	Time frame	Description
Post-Extubation Cough Grade	24 hours post operative	Cough graded according to the following criteria: Grade 0: no cough; Grade 1: mild, only 1 cough; Grade 2: moderate, \>1 cough lasting \<5 seconds; Grade 3: coughing heavily and continuously for \>5 seconds)

Secondary

Measure	Time frame	Description
Number of participant experiencing tachycardia	24 hours perioperative	Tachycardia is defined as heart rate \>100 beats per minute
Number of participant experiencing bradycardia	24 hours perioperative	Bradycardia is defined as heart rate \<60 beats per minute
Number of participant experiencing hypertension	24 hours perioperative	Increase of blood pressure \>20% from initial blood pressure
Number of participant experiencing hypotension	24 hours perioperative	Decrease of blood pressure \<20% from initial blood pressure

Countries

Indonesia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026