Influence of Risk Factors on ISR and Nonintervened Lesions

Influence of Risk Factors Such as Serum Cholesterol Level on ISR and Nonintervened Coronary Lesions

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06039059

Enrollment

510

Registered

2023-09-15

Start date

2020-01-01

Completion date

2023-03-31

Last updated

2023-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Multi Vessel Coronary Artery Disease

Keywords

ISR, nonintervened coronary lesions, risk factor

Brief summary

This study enrolled patients who used to received PCI therapy with nonintervened coronary lesions. Baseline characteristics and laboratory testing were collected to find out the risk factor difference between ISR and nonintervened coronary lesions.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Inclusion criteria

* (1) PCI therapy with drug-coated stents was performed in the past, and nonintervened coronary lesion remained except in the target vessel. (2) CAG was performed again due to re-examination, recurrent angina symptoms, positive treadmill exercise test or coronary CTA showing moderate to severe vessel diameter stenosis. (3) Long-term regular oral administration of statins and lipid monitoring were conducted after PCI.

Exclusion criteria

* Patients with a history of CABG, renal replacement therapy, autoimmune disease, and malignancy

Design outcomes

Primary

Measure	Time frame	Description
LDL-C, mmol/L	Blood samples were collected after a 12-hour fast before CAG.	Low-density cholesterol (LDL-C) is the cholesterol in low-density lipoprotein (LDL), which reflects how much LDL is present.

Secondary

Measure	Time frame	Description
HbA1c, %	Blood samples were collected after a 12-hour fast before CAG.	Hemoglobin a1c (HbA1c) is the combination of hemoglobin and blood sugar. Its concentration in the blood is stable and is not affected by short-term blood sugar concentrations. Hemoglobin A1C has obvious clinical value in the diagnosis of diabetes.
ALT, U/L	Blood samples were collected after a 12-hour fast before CAG.	Alanine aminotransferase (ALT) mainly exists in the plasma of liver cells, and the intracellular concentration is 1000-3000 times higher than that in serum. As long as 1% of liver cells are destroyed, it can double the serum enzyme. Therefore, alanine transaminase is recommended by the World Health Organization as the most sensitive detection index of liver function damage.
Scr, mmol/L	Blood samples were collected after a 12-hour fast before CAG.	Serum creatinine (Scr) is a compound produced in muscles during the production of energy. Healthy kidneys filter creatinine from the blood. Creatinine is excreted in the urine as a metabolite and is a common measure of the kidney's filtration function. Creatinine this indicator belongs to the blood biochemical test, the higher the creatinine level, usually indicates the worse the kidney function.

Countries

China

Outcome results