Oral Lichen Planus, Vitamin D Deficiency
Conditions
Brief summary
To examine how a lack of vitamin D may increase the risk of developing oral lichen planus and its malignant progression while accounting for sex, food habits, sunlight, socioeconomic level, and psychological variables.
Interventions
DEVICEELISA
Enzyme-linked immunosorbent assay (ELISA) was used following manufacturer's instructions. This test uses a competitive ELISA-based technique that was designed to quantitatively determine the concentration of 1,25-dihydroxyvitamin D3/D2 in human serum.
Sponsors
Fayoum University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* (Group A) patients presenting with a clinical picture and histological findings that confirm the diagnosis of OLP * (Group B) age, sex, and dietary habits matched healthy controls.
Exclusion criteria
* (1) subjects who have been receiving any kind of VD supplements, multivitamins, or any drug that may affect VD measurements * (2) patients with suspected restoration-related or smokeless tobacco-related lesions. * (3) patients with any systemic medical condition or pregnant females. * (4) patients with VD toxicity (VD≥100 ng/ml).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum vitamin D level in OLP | 1 month | measured by ELISA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| serum vitamin D level in correlation with sex, dietary habits and sun exposure. | 1 month | Questionnaire, measured in proportions |
| serum vitamin D level in correlation with socioeconomic status | 1 month | Kuppuswamy's socioeconomic status scale |
| serum vitamin D level in correlation with Psychological factors | 1 month | Depression Anxiety and Stress Scale 21 (DASS-21) |
Countries
Egypt
Outcome results
None listed