Healthy
Conditions
Keywords
Arabinoxylan, fiber-enriched product, glycemia, insulin, appetite
Brief summary
The aim of the present pilot randomized controlled trial is to compare the effects of the following: 1)-panettone enriched with arabinoxylans (p-rich), 2)-panettone not enriched (p-standard) on blood glucose and insulin values, and appetite scores in 10 healthy volunteers.
Detailed description
This is a crossover, randomized double-blind trial. A product enriched with arabinoxylan extracted from threshing (panettone, p-rich, a sweet baked product with a high glycemic index) was developed to assess the impact on metabolic responses and satiety when compared to the standard product (p-standard) . Ten Caucasian non-smoker healthy adult volunteers were enrolled starting from January 2023. Participants were randomized to receive either the p-rich or p-standard. The order of administration of each product was randomized using a computer-generated sequence. The day of each test, fasting individuals underwent a blood sample collection, and weight and height measurements. Then, participants consumed 100 grams of the product within 20 minutes, while sitting. Blood samples were collected at 15, 30, 45, 60, 90, 120 minutes after the consumption of each food.
Interventions
OTHEREnriched panettone
Volunteers consumed 100 grams of panettone enriched with fiber (JAX Plus® (Heallo srl, Milano, Italy), a soluble fiber with Arabinoxylans from wheat and barley
OTHERPanettone standard
Volunteers consumed 100 grams of panettone standard
Sponsors
University of Turin, Italy
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Neither the participant nor the investigators were aware of the composition of the administered food. The two types of foods were identical for packages, color, flavor, smell, and appearance. Furthermore, the researchers who analyzed data and the laboratory personnel who performed the biochemical analyses were blinded to the group assigned.
Intervention model description
crossover randomized double-blind trial
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* non-smokers healthy adults; * age 20-65 years; * ability to provide informed written consent
Exclusion criteria
* obesity; * chronic diseases or pharmacological therapies; * dietary restrictions; * allergy or intolerance to the tested food
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in circulating concentrations of glucose | 15, 30, 45, 60, 90, 120 minutes after the consumption of each food | To evaluate changes in glucose responses after the consumption of p-rich when compared to p-standard |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in circulating concentrations of insulin | 15, 30, 45, 60, 90, 120 minutes after the consumption of each food | To evaluate changes in insulin responses after the consumption of p-rich when compared to p-standard |
| Changes in subjective appetite score (VAS) | 60, 120, 180, and 240 minutes after the consumption of each food | To evaluate changes in appetite responses after the consumption of p-rich when compared to p-standard. Subjective sensations of appetite were assessed by a visual analogue scale (VAS) ranging from 0 to 10. |
Countries
Italy
Outcome results
None listed