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Mechanism for Exercise to Delay Cardiac Aging

The αKlotho Protein-mediated NLRP3/Caspase-1/GSDMD Pathway Counteracts Myocardial Stunning: a Novel Mechanism for Exercise to Delay Cardiac Aging

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06031675
Enrollment
40
Registered
2023-09-11
Start date
2023-05-12
Completion date
2023-09-01
Last updated
2023-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Activity, Motor, Health Behavior

Keywords

vigorous intermittent lifestyle physical activity, wearable device, isokinetic performance

Brief summary

The goal of this clinicaltrial is to assess and compare isokinetic performance, surface electromyography, laboratory parameters, and cardiorespiratory function both before and after engaging in vigorous intermittent lifestyle physical activity(VILPA) within a healthy population. The main question it aims to answer is: \[1\] Does VILPA yield effective outcomes? Throughout the course of the trial, participants will engage in a simulated regimen of vigorous intermittent lifestyle physical activity for a duration of 8 weeks. The efficacy of the exercise protocol will be quantified and evaluated through the utilization of a wearable device.

Interventions

The specific exercise regimen involves performing rope jumping activities three times a day, with each session aimed at surpassing the exercise threshold (not conducted in a continuous manner), where the heart rate should exceed 160 beats per minute. This routine will be undertaken five times a week, continuously for a span of 8 weeks.

Sponsors

Xiao-dong Zhuang
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. Healthy Adults 2. No exercise habits (more than 3 months)

Exclusion criteria

1. Exercising ≥ 3 times per week; 2. the presence of chronic diseases, such as hypertension, hyperglycemic states, etc; 3. have conducted an exercise program in the past three months.

Design outcomes

Primary

MeasureTime frameDescription
Exercise Flat Test30 minutescardiopulmonary function
Isometric Strength Test15 minutesIsokinetic muscle strength testing with the Isomed 2000
Surface electromyography30 minutes

Secondary

MeasureTime frame
Fasting glucose5 minutes
Blood lipid5 minutes

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026