Electrolyte Imbalance, Kidney Transplant; Complications
Conditions
Brief summary
This is a randomized controlled pragmatic clinical trial. We aim to evaluate the effect of Ringer lactate solution (RLS) and normal saline solution (NSS) with dextrose water (D5W) on the electrolyte abnormality of kidney transplant recipients (KTR) during the first post-operative week. The problem with using NSS with or without D5W as a standard replacement fluid is the hyperchloremic metabolic acidosis which might compromise the kidney allograft function. A total 60 KTRs per arm will be enrolled and randomized to receive either RLS or NSS with D5W. The primary outcome is serum bicarbonate level at day 4 after transplantation. Secondary outcomes include the serum potassium, serum sodium, serum chloride, cytokine panel, and the incidence of delayed graft function.
Interventions
The patient will receive RLS as a replacement fluid for urine output (mL per mL) until the patient have sufficient oral intake and fluid can be removed.
DRUGNormal saline
The patient will receive NSS with D5W as a replacement fluid for urine output (mL per mL) until the patient have sufficient oral intake and fluid can be removed.
Sponsors
King Chulalongkorn Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* A kidney transplant recipient who receives transplant at King Chulalongkorn Memorial Hospital. * Age \>=18 years * Both deceased donor and living donor kidney transplantation will be included
Exclusion criteria
* multiorgan transplantation * Known allergy to RLS or NSS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum bicarbonate level | Day 4 after transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum potassium level | Day 4 after transplantation | — |
| Serum chloride level | Day 4 after transplantation | — |
| Serum sodium level | Day 4 after transplantation | — |
| Immune function marker | Day 4 after transplantation | TNF-alpha |
Countries
Thailand
Outcome results
None listed