Efficacy of Repetitive Transcranial Magnetic Stimulation in Adult Attention Deficit Disorder

An Open-lable Investigation of the Effect of rTMS on Attention in an Adult Sample Suffering From ADD

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06030024

Enrollment

Registered

2023-09-08

Start date

2021-09-01

Completion date

2023-03-01

Last updated

2023-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD, Attention Deficit Disorder

Keywords

rTMS, ADHD, ADD, fMRI

Brief summary

The purpose of the current open-lable study was to use low-frequency repetitive transcranial magnetic stimulation (rTMS) to improve the attention deficits in a sample of adult patients suffering from attention deficit disorder. Participants received 10 sessions of rTMS over Fz (located using the EEG 10-20 international system) and underwent assessments of their attentional capacity using the gradCPT task in an fMRI scanner, before and after the intervention. Other behavioral assessments of their attention symptoms have also been conducted.

Interventions

DEVICErepetitive Transcranial Magnetic Stimulation

Magnetic pulses delivered to the Fz area of the brain in a low frequency (1 Hz) manner.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Normal intelligence level (\>90) * Diagnosis of ADD by a psychiatrist using the ADHD-RS-IV with Adult Prompts

Exclusion criteria

* Scores of 21 or more on BDI and/or BAI * History of head trauma * History of a major psychological or neurological condition * Presence of metal in the head * History of seizures * Serious cardiovascular disease * Use of medications with an impact on cognitive functions during the treatment window (patients with a constant and stable dose were included) * Recent use of alcohol or substance abuse

Design outcomes

Primary

Measure	Time frame	Description
Change in performance	Up to 10 days, i.e., before and after the completion of the 10 sessions of rTMS	Shortened version (4 min) of the continuous go/no-go task: gradual-onset continuous performance task (gradCPT)

Secondary

Measure	Time frame	Description
Change in self-report attention scores	Baseline, after 5 days of stimulation, after 10 days of stimulation; Range= 0-6; Higher scores represent worse outcome	The 6-item ASRS-V1.1 Adult ADHD Self-Report
Change in investigator-rated attention scores	Baseline, after 5 days of stimulation, after 10 days of stimulation; Range:0 - 54; Higher scores represent worse outcome	Investigator-Rated Attention-Deficit Hyperactivity Disorder (ADHD) Rating Scale-IV (I-ADHD RS-IV) with adult prompts

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026