Healthy, Myopathies, Inflammatory, Rheumatoid Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis
Conditions
Brief summary
Objectives: Systemic autoimmune diseases are chronic diseases characterized by chronic inflammation, vasculopathy, and autoimmune phenomena. Several organ involvements are typical, including the central nervous system. Formerly published investigations emphasize a mild cognitive impairment affecting attention, memory, and complicated solution tasks. However, these symptoms significantly impact patients' routines and quality of life. The study examined the associations between cognitive impairment and clinical parameters regarding systemic autoimmune diseases. Methods: General clinical data, some serum biomarkers including CCl-18, YKL-40, COMP, VEGF, Galectin-3, and Pentraxin as well as results of functional, quality of life, and neuropsychological measures, the Mini-Mental State Examination (MMSE), the Digit Span Forward-Backward, the Trail making A, B and the Digit Symbol tests all were administered.
Interventions
None listed
Sponsors
University of Pecs
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Systemic autoimmune diseases * Healthy individuals - as controls
Exclusion criteria
* Diseases of the central nervous system * Presence of pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mini-mental State Examination | 12 months | Complex Cognitive measure |
| The Functional Assessment of Chronic Illness Therapy F | 12 months | health-related quality of life measure |
Countries
Hungary
Outcome results
None listed