Diastolic Function in Myotonic Dystrophy Type 1

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06029192

Enrollment

500

Registered

2023-09-08

Start date

2023-06-02

Completion date

2023-11-01

Last updated

2023-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diastolic Dysfunction

Brief summary

Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) . The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Inclusion criteria

* patients with genetic proven myotonic dystrophy type 1 * who experienced a Doppler- Echocardiography including an assessment of the left ventricular diastolic function

Exclusion criteria

* wall motion basal abnormalities * significant valvular disease

Design outcomes

Primary

Measure	Time frame
mortality	7 years

Secondary

Measure	Time frame
Incidence of arrhythmia	7 years
acute heart failure	7 years

Countries

France

Contacts

Primary ContactAbdallah FAYSSOIL, MD PhD

abdallah.fayssoil@aphp.fr+33147107778

Outcome results