NSAID-Associated Gastropathy
Conditions
Keywords
Magnetically-controlled Capsule Endoscopy
Brief summary
The objective of this study is to observe gastric mucosal injuries in NSAID and non-NSAID users with magnetically-controlled capsule gastroscopy, and explore the effects of NSAIDs on gastric mucosal damage.
Detailed description
Non-steroidal anti-inflammatory drugs are widely used in all kinds of people in China. A major limitation to their use is the adverse effects they cause on the gastrointestinal tract, including the formation of stomach lesions, ulcers due to stress reactions, and damage to the healing of gastric ulcers. The purpose of this prospective, single-center study was to monitor the gastric mucosal injury in patients with and without NSAIDs using magnetron capsule gastroscopy, and to explore the effect of NSaids on gastric mucosal injury. For people taking NSAIDs, it is necessary to regularly detect gastric mucosal damage, and timely intervention treatment is required if relevant lesions are found, and the medication plan is adjusted. Magnetron capsule gastroscope has the advantages of comfort, safety, no anesthesia, no risk of cross infection, etc. It is highly accepted by the population, and is a beneficial supplement to traditional gastroscopy, so that some people with absolute or relative contraindications of traditional gastroscopy can get timely endoscopy, and can be diagnosed and treated early.
Interventions
None listed
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Planned magnetically-controlled capsule gastroscopy * NSAID use \>3 months or no NSAID use * Informed consent
Exclusion criteria
* No surgical conditions or refuses abdominal surgery (Once the capsule is stuck it cannot be removed surgically); * Cardiac pacemakers (except MRI-compatible ones); * Electronic implants or metal foreign bodies; * Pregnant women; * Known or suspected GI obstruction, stenosis, fistula; * Dysphagia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastric diseases detected | 1 day | Gastric diseases detected |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gastric mucosal injury by Lanza score | 1 day | Gastric mucosal injury by Lanza score |
| Gastric transit time | 1 day | Gastric transit time |
| Gastric cleanliness | 1 day | Gastric cleanliness |
| Effects of NSAID duration on gastric injury | 1 day | Effects of NSAID duration on gastric injury |
| Effects of NSAID dosage on gastric injury | 1 day | Effects of NSAID dosage on gastric injury |
Countries
China
Outcome results
None listed