Cancer, Positron Emission Tomography, Radioembolization, Radiotherapy
Conditions
Brief summary
Hypoxia is a known factor for resistance to radiotherapy in tumors. Response to transarterial radioembolization is known to be variable between different patients even if the same dose of radiation was delivered. In this study the investigators aim to quantify the hypoxia in the primary and secondary tumors of liver with 18F-FMISO PET before radioembolization and to prove any effect of the hypoxia, if present, on the dose that should be delivered to tumor to ensure treatment response.
Interventions
DIAGNOSTIC_TEST18F-Fluoromisonidazole PET
Imaging of hypoxia before radioembolization with 18F-Fluoromisonidazole PET.
Sponsors
Ankara University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Diagnosed with colorectal carcinoma with liver metastasis or hepatocellular carcinoma. * Is not eligible for surgery * Above 18 years old * The patients who are referred for transarterial radioembolization treatment to Ankara University School of Medicine Department of Nuclear Medicine.
Exclusion criteria
* Patients with ECOG performance score \>1 * Claustrophobia * Life expectancy shorter than 3 months * Pregnant or breast-feeding patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Demonstrate the effect of the hypoxia in the success of the radioembolization treatment | 08/2024 | Demonstrate the effect of the hypoxia in the success of the radioembolization treatment |
| The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group. | 08/2024 | The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group. |
Countries
Turkey (Türkiye)
Outcome results
None listed