Colo-rectal Cancer
Conditions
Keywords
Colo-rectal cancer, spectral CT scan, liver metastases, peritoneal carcinosis
Brief summary
Spectral CT is a rapidly expanding imaging modality that allows a reduction in iodine dose and irradiation compared to conventional scanning. It uses the difference in attenuation of the material according to the two different energy levels of the incident x-ray beams. The dual-energy scanner has a wide range of clinical applications, particularly in abdominal imaging.
Detailed description
First of all, the virtual creation of mono-energy images between 40 and 140 keV has shown subjective and objective improvement of tumor detection of hypovascular lesions using low energies (40keV). It has been shown to be of interest in vascular and cardiac imaging, and to reduce artefacts in bone imaging. However, its performance in oncology analysis has been little studied. The selection of patients for peritoneal and hepatic carcinosis surgery is fundamental, as surgery allows a prolongation of survival, but are associated with a non-negligible morbi-mortality rate. Spectral CT provides improved detection of peritoneal carcinosis and liver metastases of colorectal cancer compared to conventional CT acquisition.
Interventions
OTHERCT Images
Analysis of CT images of peritoneal and/or liver metastases from colorectal cancer
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients followed for colorectal cancer with synchronous or metachronous liver metastases and/or peritoneal carcinosis * Patients with a curative surgical resection plan
Exclusion criteria
* Patients with non-metastatic colorectal cancer * Patients treated with chemotherapy without surgical plans * Patients with colorectal cancer with extra-hepatic and extra-peritoneal metastases alone (e.g. lung, bone)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of peritoneal lesion mapping between spectral scanning and conventional scanning | Year : 1 | Comparison of peritoneal lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition). |
| Comparison of hepatic lesion mapping between spectral scanning and conventional scanning | Year : 1 | Comparison of hepatic lesion mapping between spectral scanning (monoenergetic acquisitions, iodine mapping, etc.) and conventional scanning (acquisition obtained during spectral acquisition). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of response to chemotherapy in RECIST 1.1 | Year : 1 | Collection of demographic, biological and surgical data. |
| Evaluation of response to chemotherapy in Radiomics | Year : 1 | Collection of demographic, biological and surgical data. |
Countries
France
Contacts
Primary ContactRémi GRANGE, MD
Backup ContactSylvain GRANGE, MD
Outcome results
None listed