Juvenile Idiopathic Arthritis
Conditions
Brief summary
The fibrinogen to albumin ratio (FAR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between FAR/CAR and Juvenile arthritis disease activity score (JASDAS27) in Juvenile idiopathic arthritis (JIA)
Detailed description
The JADAS27 includes a selected count of the following joints: cervical spine, elbows, wrists, metacarpophalangeal joints (from first to third), proximal interphalangeal joints, hips, knees and ankles.
Interventions
DIAGNOSTIC_TESTfibrinogen to albumin ratio (AFR) and C-reactive protein to albumin ratio (CAR)
measurement of serum albumin, fibrinogen and CRP
Sponsors
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
Yes
Inclusion criteria
* All juvenile idiopathic arthritis fulfilling the criteria of International League of Associations for Rheumatology (ILAR) and age and sex matched healthy subjects
Exclusion criteria
* Other systemic inflammatory or autoimmune disorders. * History of corticosteroid medication in the last 6 months. * Liver diseases. * Malignancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The fibrinogen to albumin ratio | 3 months | measurement of serum fibrinogen and albumin |
| The CRP to albumin ratio | 3 MONTHS | measurement of serum CRP and albumin |
| Correlation of fibrinogen to albumin and CRP to albumin ratios on one side with disease activity on the other side | 3 MONTHS | correlation of these ratios with JADAS27 |
Outcome results
None listed