Infertility
Conditions
Brief summary
The goal of this clinical trial is to compare the clinical outcomes using different cetrorelix acetate in the context of a GnRH antagonist protocol for ovarian stimulation in women undergoing IVF or intracytoplasmic sperm injection(ICSI) treatment.The main question it aims to answer is whether the generic cetrorelix acetate is non-inferior to the reference product in the GnRH antagonist based protocol for women undergoing IVF. Ovarian stimulation was achieved by several types of follicle-stimulating hormone(FSH) or by FSH combined with luteinizing hormone activity. Daily dose of generic cetrorelix acetate (0.25 mg SC) or original cetrorelix acetate (0.25 mg SC) will be administered when the lead follicle was 14 mm. When more than two follicles reached 17 mm, oocyte maturation was triggered with 250 mcg of recombinant human chorionic gonadotropin.
Interventions
DRUGGeneric cetrorelix acetate
Generic cetrorelix acetate (0.25 mg SC)
DRUGReference cetrorelix acetate
reference cetrorelix acetate (0.25 mg SC)
Sponsors
Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* Infertile couples plan to undergo IVF / ICSI pregnancy treatment into screening procedures and clinical study 1. All subjects should sign the informed consent form 2. Infertile women \<43 years old 3. With flexible GnRH antagonist
Exclusion criteria
* Subjects could not enter the study if they meet any one of the following criteria 1. Preimplantation Genetic Testing (PGT) 2. Untreated hydrosalpinges, moderate or severe endometriosis, recurrent spontaneous miscarriage, endometrial pathology, uterine malformations, etc 3. Endocrine diseases (such as hyperthyroidism, hyperprolactinemia, etc.) or other systemic disease and other systemic diseases (such as hypertension, diabetes, etc.)． 4. Other factors were considered inappropriate by the investigator to participate, or assisted reproductive technology/pregnancy contraindications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cumulative live birth rate | Through study completion, an average of 18 months | For the first live birth (gestation≥ 24 weeks) in one in vitro fertilization/intracytoplasmic sperm injection egg retrieval cycle (fresh and frozen-thawed embryo transfer cycle) |
Countries
China
Contacts
Primary ContactHE CAI, Doctor
Backup ContactJuanzi Shi, Doctor
Outcome results
None listed