Metastasis Spinal Tumor
Conditions
Keywords
Tranexamic Acid, blood loss, seperation surgery
Brief summary
Massive blood loss occurs in metastatic spinal tumor resection and may cause severe complications. The objective of this study is to investigate whether the use of tranexamic acid will reduce perioperative and postoperative bleeding when compared to those without use of tranexamic acid.
Interventions
DRUGTranexamic Acid
IV drip of 2 bottles of tranexamic acid (2g) before making incision during surgery； 1g tranexamic acid soaked gauze applied to the wound for 5 minintes before suture； patients were administered IV drip of tranexamic acid 3 times (every 8 hours)within 24 hours after surgery.
DRUGstroke-physiological saline solution (SPSS)
IV drip of 2 bottles of saline before making incision during surgery； saline soaked gauze applied to the wound for 5 minintes before suture； patients were administered IV drip of saline 3 times (every 8 hours)within 24 hours after surgery.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
10 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed as metastatic carcinoma of the thoracolumbar spine * solitary neoplasm involve only one segment of spine * patients underwent separation surgery
Exclusion criteria
* coagulation function was abnormal preoperatively * patients are allergic to tranexamic acid * neoplasm involve more than one segment of spine * patients with rich blood supply who need embolization
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total blood loss | measured 3 days postoperatively | the loss of total blood volume caused by various operations (mainly during surgical operations) throughout the entire treatment process. Total blood volume = preoperative blood volume \*（preoperative hematocrit - hematocrit 3 days postoperatively） |
| Intraoperative blood loss | 1 day (measured once after surgery) | Refers to the total blood loss of a patient experienced during operation from skin incision to wound suture. Intraoperative blood loss = intraoperative drainage volume - intraoperative flushing volume + blood loss estimation using gauze (calculated as 10 cm × 10 cm gauze absorbs 10 ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| allogeneic transfusion blood volume | 1 day (measured once during surgery) | amount of allogeneic transfusion blood volume needed during operation |
Countries
China
Contacts
Primary ContactHengyuan Li, MD
Outcome results
None listed