FindTrial
Sign In

Prospective Validation of CARPET Prognostic Model for Septic Shock After Allo-HSCT

Prospective Validation of CARPET Prognostic Model for Patients With Septic Shock After Allogeneic Hematopoietic Stem Cell Transplantation

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06022445
Enrollment
200
Registered
2023-09-01
Start date
2023-09-01
Completion date
2024-12-30
Last updated
2023-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stem Cell Transplant Complications

Keywords

septic shock, prognostic model, allogeneic hematopoietic stem cell transplant

Brief summary

Validation of CARPET prognostic model for septic shock after allo-HSCT: a multicenter, prospective, and cohort study

Detailed description

A clinical prognostic model named CARPET model for septic shock after allo-HSCT has been developed and internally retrospectively validated. A multicenter, prospective cohort study is planned to validate this clinical prediction model again. The equation of the prediction model for 28-day mortality was as follows: Probability(28-day mortality)=(exp⁡(Y))/(1+exp⁡(Y)) where Y=2.343+1.328\* Time of septic shock- 0.085\* Albumin + 0.016 \* Bilirubin-0.003\*PaO2/FiO2 +0.127\*Lactate- 0.011 \* Glomerular filtration rate

Interventions

OTHERCARPET prognostic model

For patients diagnosed with septic shock, we obtained the information in CARPET prognostic model including time of septic shock, albumin, bilirubin, PaO2/FiO2, lactate, and GFR. We calculated the CARPET risk score and the 28-day mortality probability according to CARPET logistic regression model.

Sponsors

Navy General Hospital, Beijing
CollaboratorOTHER
Second Hospital of Shanxi Medical University
CollaboratorOTHER
The Second Hospital of Hebei Medical University
CollaboratorOTHER
Shanghai Zhongshan Hospital
CollaboratorOTHER
Shanxi Dayi Hospital
CollaboratorOTHER
People's Hospital of Xinjiang Uygur Autonomous Region
CollaboratorOTHER
Guangzhou University of Chinese Medicine
CollaboratorOTHER
The First Affiliated Hospital of Zhengzhou University
CollaboratorOTHER
Peking Union Medical College
CollaboratorOTHER
First Affiliated Hospital of Harbin Medical University
CollaboratorOTHER
Peking University People's Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* age \>18 years * underwent allo-HSCT * diagnosed with septic shock

Exclusion criteria

* experienced septic shock before enrollment * relapsed or progressed after HSCT

Design outcomes

Primary

MeasureTime frameDescription
28-day mortality28 daysDead or alive at day 28 after septic shock diagnosis

Secondary

MeasureTime frameDescription
ICU length of stayup to 1 yearDays in the ICU after septic shock diagnosis
90-day mortality90 daysDead or alive at day 90 after septic shock diagnosis
Time on ventilatorup to 1 yearDays in need of mechanical ventilation

Countries

China

Contacts

Primary ContactXiaohui Zhang, MD
zhangxh@bjmu.edu.cn+86 13522338836

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026