Ozonated Water in Treatment of Denture Stomatitis

Effect of Ozone Water in Treatment of Denture Inflammation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06021847

Enrollment

Registered

2023-09-01

Start date

2023-05-01

Completion date

2023-06-01

Last updated

2023-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Denture Stomatitis

Keywords

Ozonated water, denture stomatitis, Chlorhexidine mouthwash

Brief summary

The effect of Ozonated water on the treatment of oral stomatitis associated with complete denture wearer in comparison to Chlorhexidine mouthwash

Detailed description

Compete denture wearers having oral denture stomatitis were divided into two groups. group I used Ozonated water while group II used Chlorhexidine mouthwash. The growth of Candida albicans, the degree inflammation and pain grade were evaluated before starting the treatment then every week till one month. Also

Interventions

OTHEROzonated water

ozonated water was prepared with a concentration of (2-4 mg/l) ozone for 1 min. in a 25 mg of double distilled water 37o C employing an Ozone generator (Ozone generator type N 1888A, China.)

OTHERChlorhexidine mouthwash

Commercial available chlorhexidine mouthwash in the market was used.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Masking description

The patients didn't know which treatment they received.

Intervention model description

Two groups ( complete denture wearers with oral stomatitis). Group I treated with ozonated water while group II treated with chlorhexidine mouthwash.

Eligibility

Sex/Gender

MALE

Healthy volunteers

Inclusion criteria

* Completely edentulous male patients wearing heat cured acrylic resin removable prosthesis. * Patients having denture associated oral stomatitis. * Healthy patients free of any systemic diseases.

Exclusion criteria

* Smoker patients. * Patients suffering from any auto immune or systemic diseases, Temporo-mandibular joint disorder ( TMJ disorders and parafunctional oral habits. * Patients with a history of radiotherapy or chemotherapy. * Patients having oral lesions.

Design outcomes

Primary

Measure	Time frame	Description
Candida albicans colonies	day one, 7th day, 14th day and 30th day	The number of Candida albicans forming units (CFU) was used to assess the effect of two types of treatments.

Secondary

Measure	Time frame	Description
-Evaluation of inflammation and pain grade	day 1, and 30th day	\- Evaluation of inflammation and pain grade by questionnaire

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026