Cutaneous Squamous Cell Carcinoma, Metastasis, Pathology, Recurrence
Conditions
Keywords
Interobserver variability, Interobserver agreement, Reproducibility, Dermatopathologist, Desmoplasia
Brief summary
According to the most recent guideline of the National Comprehensive Cancer Network (NCCN), desmoplasia is considered to be a very high risk factor for recurrence, metastasis and death in cutaneous squamous cell carcinoma (cSCC). The presence of desmoplasia is assessed by dermatopathologists during histological examination of cSCCs. However, the inter-observer agreement is between dermatopathologists in the assessment of desmoplasia is unclear. Studies on inter-observer variability in the assessment of differentiation grade in cSCCs showed that there is only a weak to moderate agreement among dermatopathologists in the assessment of differentiation grade (2-4). This study aims to investigate the interobserver agreement of desmoplasia between dermatopathologists. In this prospective study, 50 cSCCs will be assessed for desmoplasia by at least eight dermatopathologists using a predefined definition.
Interventions
OTHERAssessment by dermatopathologists
Histological assessment of the cSCCs by eight dermatopathologists.
Sponsors
Maastricht University Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Histological coupes of patients with a cSCC between 2010 and 2018 (both cSCC with and without desmoplasia are included) * Treated at the Maastricht University Medical Center+ (MUMC+)in Maastricht for their cSCC * Of which the histology is available in the MUMC+
Exclusion criteria
\- None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Interobserver agreement | Through study completion, an average of 2 months | Interobserver agreement between dermatopathologists in the assessment of desmoplasia, expressed as percentages and Fleiss' kappa (Landis and Koch, see below) \<0 Poor agreement 0.0-0.20 Slight agreement 0.21-0.40 Fair agreement 0.41-0.60 Moderate agreement 0.61-0.80 Substantial agreement 0.81-1.00 Almost perfect agreement |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Definitions used | Before the histological assessment, at baseline. | A description of the different definitions of desmoplasia used by the dermatopathologists. |
Countries
Netherlands
Outcome results
None listed