Cystic Fibrosis, Frailty Syndrome
Conditions
Keywords
functional status, frailty, Cystic Fibrosis, geriatric syndrome
Brief summary
The goal of this observational study is to assess the main clinical and anamnestic characteristics, and frailty syndrome in an adult Cystic Fibrosis population. The main question it aims to answer is the possible association of the frailty status with the main clinical, therapeutical characteristics, including the genotyping classification of Cystic Fibrosis patients.
Detailed description
Participants will be assessed for the pulmonary status by spirometry (for Forced Expiratory Volume in 1 second \[FEV1 - L\]; Forced Expiratory Volume in 1 second percent predicted \[ppFEV1%\]; Forced Vital Capacity \[FVC - L\]; Forced Vital Capacity percent predicted \[FVC %\]; Maximal Mid-Expiratory Flow \[MMEF\]); for the functional status by evaluating the activities of daily living \[ADLs\], and the instrumental ADLs \[IADLs\]; and for frailty by the Study of Osteoporotic Fractures \[SOF\] Index. The height and weight will be also recorded, and Body Mass Index \[BMI\] calculated as body weight divided by height squared \[Kg/m2\]. Body weight will be measured in a fasting state in the morning with a mechanical balance.
Interventions
None listed
Sponsors
Federico II University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* who met the diagnostic criteria for CF, * over 18 years old, * pathological sweat chloride levels (chloride \>60 mEq/L) and two CFTR mutations
Exclusion criteria
* who did not meet the diagnostic criteria for CF * under 18 years old * over 18 years old with normal sweat chloride levels (chloride \>60 mEq/L)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pre-Frail/Frail Status | through study completion, an average of 1 year | Frailty has been assessed by the SOF Index |
Countries
Italy
Outcome results
None listed