Hypertension,Essential
Conditions
Brief summary
Out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. The aim of this study is to analyze the association between licorice intake and home blood pressure.
Detailed description
For a detailed background, please see Clinical Trials registration number NCT05661721. In brief, out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. In a previous study, the response to licorice intake varied between participants. The aim of this study is to analyze the response of the most licorice sensitive quartile of participants from the original study to lower dosages of licorice, corresponding to 20 and 50 milligram och GA daily.
Interventions
OTHERLicorice
Ecologic sweet licorice pastilles made from Glycyrrhiza glabra grown in Calabria, Italy, with a GA content of 29.9 ±2.0 mg/g.
Sponsors
Linkoeping University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 31 Years
Healthy volunteers
Yes
Inclusion criteria
* Previous participation in the Licorice and home blood pressure study (NCT05661721).
Exclusion criteria
* Known hypertension, cardiovascular disease, kidney disease, liver disease, hormonal disease, peanut allergy, eating disorder or headache disease (including tension headache and migraine) * Known alcohol abuse or drug abuse (including cannabis and anabolic steroids) treatment with hormonal drugs (including oral contraceptives * Known intolerance to licorice intake.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic home blood pressure | 3 days before interventions and 28 days during intervention | Systolic home blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body weight | Day 0, 14 and 28 | Body weight |
| Plasma sodium | Day 0, 14 and 28 | Plasma sodium |
| Plasma potassium | Day 0, 14 and 28 | Plasma potassium |
| Diastolic home blood pressure | 3 days before interventions and 28 days during intervention | Diastolic home blood pressure |
| Plasma N-terminal pro B-type natriuretic peptide | Day 0, 14 and 28 | Plasma N-terminal pro B-type natriuretic peptide |
| Plasma renin | Day 0, 14 and 28 | Plasma renin |
| Serum aldosterone | Day 0, 14 and 28 | Serum aldosterone |
| Plasma creatinine | Day 0, 14 and 28 | Plasma creatinine |
Countries
Sweden
Outcome results
None listed