Atrial Fibrillation, Embolism, Infarction, Brain
Conditions
Keywords
Infarction, Embolism, Atrial Fibrillation, Ultrasound, Transcranial Doppler
Brief summary
This multicenter international prospective cohort study will include patients with AIS with a known or newly diagnosed anticoagulant-naïve AF. All centers will use the same transcranial Doppler machine for one-hour monitoring with bilateral 2-MHz probes within 24 hours of symptom onset. Recordings will be analyzed for MES by a blinded central reader. The primary aim is to determine the proportion of patients with MES and the association of MES with functional outcomes assessed by a modified Rankin scale (mRS) score at 90 days.
Interventions
OTHERThe presence and rate of MES measured by TCD monitoring
TCD monitoring within 24 hours from the last known well time. Bilateral M1 segments of middle cerebral artery were insonated at a single depth with 2-MHz transducers secured by a probe-holder.
Sponsors
University of Giessen
University of Padova
University of Ostrava
Clinical Hospital Centre Zagreb
Centro Hospitalar De São João, E.P.E.
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* acute ischemic stroke admitted to the Stroke Unit, history of AF/flutter or a new diagnosis of AF at the stroke, and with a possibility to be monitored within 24 hours after symptom onset.
Exclusion criteria
* use of anticoagulants at stroke onset; prosthetic valves; inadequate temporal bone window; uncooperative patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of MES | Within 24 hours of symptom onset |
| Poor functional outcome | 90-days after stroke |
Secondary
| Measure | Time frame |
|---|---|
| Ordinal Shift Analysis of mRS scale score | 90-days after stroke |
Countries
Portugal
Outcome results
None listed