Osteoporosis, Sarcopenia
Conditions
Keywords
muscle strength, bone mineral density
Brief summary
Bone and skeletal muscle are in a single unit that interacts with each other structurally and functionally. The aim of this study is to determine the contribution of bone myoregulation reflex as a neuronal crosstalk mechanism on the development of sarcopenia in postmenopausal and senile osteoporosis
Detailed description
Bone and skeletal muscle are in a single unit that interacts with each other structurally and functionally. While myokines synthesized and released in skeletal muscle modulate the bone formation and destruction process, osteokines synthesized and released by bone cells have positive or negative effects on muscle (4,5,6,7,8,9). In addition to humoral crosstalk mechanisms between muscle and bone, there is also a neuronal crosstalk mechanism defined as bone myoregulation reflex. The aim of this study is to determine the contribution of bone myoregulation reflex as a neuronal crosstalk mechanism on the development of sarcopenia in postmenopausal and senile osteoporosis (10,11,12,13,14). Osteoporotic cases would be determined by standard DXA measurements. The vibration will be applied with the PowerPlate® Pro5 whole-body vibration (London UK) device. The vibration amplitude will be 2 mm. The vibration frequency will be 30, 33, and 36 Hz. Each vibration frequency will be applied for 45 seconds. A 5-second rest period will be applied between vibrations of 45 seconds. Surface EMG recordings will be taken from the right soleus muscle using the bipolar technique. A pair of self-adhesive Ag/AgCl (Redline®) electrodes will be adhered to the skin according to the SENIAM protocol(2). Recordings will be taken in the 1-500 Hz frequency band. Surface electromyography (EMG) recordings will be taken with a PowerLab ® (ADInstruments, Oxford, UK) data recorder with a sample rate of 20 KHz. EMG recordings will be analyzed offline with LabChart7 Pro® version 7.3.8 (ADInstruments, Oxford, UK). The acceleration measurement data will be recorded with the PowerLab (ADInstrument London) data acquisition simultaneously with the EMG recording. Acceleration recording will be made with a sample rate of 20 KHz.
Interventions
DEVICEwhole-body vibration to Control
Whole-body vibration (WBV) will be applied while standing upright. During this position, he will be asked not to voluntarily contract the calf muscles and to remain relaxed. The vibration will be applied with the PowerPlate® Pro5 WBV (London UK) device. The vibration amplitude will be 2 mm. The vibration frequency will be 30, 33, and 36 Hz. Each vibration frequency will be applied for 45 seconds. A 5-second rest period will be applied between vibrations of 45 seconds.
Sponsors
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* For healthy young adults control Healthy volunteers aged 20-45 years * For postmenopausal osteoporosis Hip DXA T-score (neck or total hip) \< -2.5 * For the Senile osteoporosis Over 65 years Male Hip DXA T-score (neck or total hip) \< -2.5 Female
Exclusion criteria
* Osteopenic cases * Possible sarcopenia (according to EWGSOP2 criteria) * Vertigo * Kidney stone * Panic attack story * Secondary osteoporosis * Those with polyneuropathy, central nervous system disease clinic/history * Myopathies (steroid, vitamin D deficiency, primary muscle diseases, etc.) * Cases with lesions on the soleus skin * History of fracture in lower extremity, joint prosthesis * Lower extremity active/acute thrombophlebitis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone myoregulation reflex latency | up to 2 weeks | It was defined as the period between the onset of effective mechanical stimulation and the onset of the reflex in surface electromyography. |
Countries
Turkey (Türkiye)
Outcome results
None listed