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Acute Effect of Motor-Cognitive Training

The Acute Effects of Brain Activation and Functional Connectivity Following Motor-cognitive Training Using Functional MRI

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06017154
Enrollment
21
Registered
2023-08-30
Start date
2023-09-17
Completion date
2024-02-05
Last updated
2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury;Sports

Keywords

injury prevention, cognition, physical performance, athletic training

Brief summary

Participants will complete a functional MRI to evaluate brain activation, functional connectivity, and behavioral performance immediately before and after a training program (approximately 30 minutes). The training program will comprise of integrate neuromuscular (agility, dynamic postural stability, shuffling, rapid acceleration/deceleration, plyometrics, lateral shuffle, and core stability) and cognitive (reaction time, processing speed, task switching, decision-making, and working memory) challenges.

Interventions

The training will incorporate cognitive tasks which focus on reaction time, processing speed, working memory, cognitive flexibility, and inhibitory control using visual stimuli on a screen or through sensors which illuminate using LED lights. These cognitive tasks will be performed while also executing physical performance tasks that challenge static and dynamic postural stability, lateral movement, agility, and other movement patterns. The training session will last approximately 30 minutes and participants will complete up to 5 exercises

Sponsors

Ke'La H Porter
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 25 Years
Healthy volunteers
Yes

Inclusion criteria

* Physically active

Exclusion criteria

* Injury to the muscle or bone (upper extremity, lower extremity, or back) within the past 3 months * Had musculoskeletal surgery or fracture (required open reduction internal fixation or within the last 12 months) * Had a concussion or mild head injury within the last year * Have been diagnosed with any kind of neurological, vestibular, or visual disturbance that impairs mobility * Currently taking medications that affect the central nervous system * Pregnant or suspicions of being pregnant * Have metal fragments, pins, plates, or clips, shrapnel, body piercings that cannot be removed, have surgical implants or orthodontics that cannot be removed * Have claustrophobia * Have a history of cognitive impairment

Design outcomes

Primary

MeasureTime frameDescription
Change in brain activation2 hours, pre-training session and immediately post-training sessionDuring the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The level of brain activation during the task will be captured and reported.
Change in functional connectivity2 hours, pre-training session and immediately post-training sessionThe participant will complete a resting-state functional MRI scan in which they will lay still in the scanner. No task is performed during this scan. Functional connectivity (functionally related regions of the brain that are co-activated) during the scan will be captured and reported.
Change in reaction time2 hours, pre-training session and immediately post-training sessionDuring the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The reaction time in milliseconds will be captured. The change in reaction time from pre to post training session will be reported.
Change in accuracy2 hours, pre-training session and immediately post-training sessionDuring the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The percent of correct responses (accuracy) will be captured. The change in accuracy from pre to post training session will be reported.

Secondary

MeasureTime frameDescription
Heart rate35 minutes, during the training sessionHeart rate will be monitored with a noninvasive heart rate monitor that will be worn by the participant around the chest at the level of the xiphoid process. Resting heart rate will be collected prior to the start intervention then monitored and recorded throughout the training session.
Average reaction time during the intervention30 minutes, during the training sessionAverage reaction time in milliseconds will be captured during the exercises via light sensors.
Misses during the training session30 minutes, during the training sessionThe number of misses will be captured during the exercises via light sensors. A miss is considered when they deactivate the wrong sensor or don't deactivate the sensor quickly enough.
Demographic/Injury History FormOnce, pre-trainingThe demographic and injury history form is designed to capture: 1) information about the participant including age, height, weight, race, ethnicity, 2) information related to sports participation, and 3) information related to past injuries or medical conditions which are relevant to the study.
Number of errors during the training session30 minutes, during the training sessionThe number of errors will be captured during the exercises by visual observation. An error occurs when they do not complete they exercise correctly.
Rate of perceived exertion30 minutes, during the training sessionAfter each exercise the participant will be asked to rate their perceived exertion on a scale from 6 to 20, 6 indicating low perceived exertion and 20 indicating high perceived exertion
Perceived cognitive difficulty30 minutes, during the training sessionAfter each exercise the participant will be asked to rate their perceived cognitive difficulty on a scale from 1 to 10, 1 indicating low cognitive challenge and 10 indicating high cognitive challenge
Hits during the training session30 minutes, during the training sessionThe number of hits will be captured during the exercises via light sensors. A hit is considered when they deactivate the correct sensor.
Defense Veterans Pain Rating ScaleOnce, pre-trainingThe Defense Veterans Pain Rating Scale is a valid 5-item scale to assess pain magnitude and pain interference. This scale ranges from 0 to 10, 0 indicating no pain/interference and 10 indicating as bas as it could be/complete interference.
Modified Disablement In Physically Active ScaleOnce, pre-training16-item patient-reported outcome instrument that assesses physical and psychosocial status.This scale ranges from 0 to 4, 0 indicating no problem and 4 indicating severe.
NASA Physical Activity SurveyOnce, pre-trainingThis survey asks individuals to self-report their general physical activity over the past week. This survey ranges from 0 to 10, 0 indicating sedentary and 10 indicating high physical activity.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026