Effect of Spirulina on Periodontitis

Effect of Locally Delivered Spirulina Gel on Treatment of Stage II, Grade B Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06016933

Enrollment

Registered

2023-08-30

Start date

2022-07-01

Completion date

2023-07-22

Last updated

2023-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Brief summary

The purpose of this study is to assess the clinical and immunological effect of spirulina in treatment of stage II periodontitis.

Detailed description

In this study, the investigators tested the effect of spirulina gel as adjunctive of scaling and root planing in treatment of stage II, grade B periodontitis in term of probing pocket depth reduction, mean gain in clinical attachment level, and level of interleukin 6.

Interventions

DRUGspirulina gel

Patient were received spirulina gel in diseased sites. The process will be repeated at 7, 14, 21 days.

PROCEDURESRP of all teeth

Patients received oral hygiene instructions and SRP of all teeth.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

35 Years to 50 Years

Healthy volunteers

Inclusion criteria

* All the patients suffer from stage II, grade B periodonitis with attachment loss 3-4 mm and probing pocket depth ≤ 5mm.

Exclusion criteria

* Any systemic disease that affects the periodontium. · * Pregnant, postmenopausal women. · * People who take anti-inflammatory drugs, antibiotics, or vitamins within the previous 3 month. * People who use mouth washes regularly · * Participation in other clinical trials.

Design outcomes

Primary

Measure	Time frame	Description
Clinical attachment level	3 months	Clinical attachment level was measured at baseline, 1 and 3 months after gel application.
Probing pocket depth	3 months	Probing pocket depth was measured at baseline, 1 and 3 months after gel application.
Interleukin 6.	3 months	Enzyme linked immune-assay for the quantitative measurement of interleukin 6 concentration in gingival cervicular fluid at baseline, 1 and 3 months after gel application.

Secondary

Measure	Time frame	Description
Plaque Index	3 months	Plaque index was measured at baseline and at 1, and 3-months post treatment.
Gingival index	3 months	Gingival index was measured at baseline and at 1, and 3-months post treatment.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026