Sarcopenia
Conditions
Keywords
cancer, nutritional support, omega-3 enriched nutritional supplements
Brief summary
Sarcopenia is a frequent complication in patients with cancer and chronic diseases, it is characterized by decreased muscle strength and fatigue due to reduced skeletal muscle mass, which is accompanied by atrophy and decreased quality of muscle tissue. In all cases, it negatively impacts treatment tolerance, clinical outcomes and survival, in consequence, quality of life of these patients decreases while morbidity, mortality and costs increase. In this context, appropriate nutritional screening and early nutrition support are extremely recommended, to this aim, in some cases, oral nutritional supplements (ONS) are necessary; ONS could have a standard formula or be enriched with specific nutrients (arginine, glutamine, branched chain amino acids, n-3 fatty acids, and nucleotides), which can modulate the activity of the immune system and provide an additional benefit beyond the nutritional support, this intervention type is called immunonutrition. Despite these possible benefits, their utility has been proven in few clinical scenarios, for example in with patients with upper gastrointestinal cancer undergoing surgical resection; based on this, current guidelines recommend that patients should receive oral/enteral nutritional support with an specific formula enriched in immunonutrients (with arginine, n-3 fatty acids or nucleotides) , but there is a lack of evidence for supporting its use in other clinical conditions including patients with cancer that receive systemic treatment
Interventions
DIETARY_SUPPLEMENTomega-3
Take 2 omega-3 enriched oral supplements per day plus physical activity and Mediterranean Diet
DIETARY_SUPPLEMENTStandard
Take 2 hypercaloric hyperproteic oral supplements per day plus physical activity and Mediterranean Diet
Sponsors
Maimónides Biomedical Research Institute of Córdoba
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \- Patients with Gastrointestinal tumor undergoing systemic treatment (chemo-radio-immuno therapy or their combination) * Body weight loss \>5% in the previous three months or \>10% in the previous six months * Both sexes * Age between 18-85 y-old.
Exclusion criteria
* Life expectancy \< 2 weeks * MDRD \< 15 mL/min * End-stage liver disease * Any musculoskeletal, cardiovascular and/or neurological disorders that could affect exercising.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functionality | 12 weeks | Changes in functionality measured with the Up and Go Test |
| Muscle mass | 12 weeks | Muscle mass change (in Kg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Albumin | 12 weeks | Changes in serum albumin levels (g/dl) |
| C-RP | 12 weeks | Changes in serum C-RP(g/dl) |
Countries
Spain
Outcome results
None listed