Basal Cell Carcinoma, Complication, Complication of Surgical Procedure, Complication,Postoperative, Cutaneous Squamous Cell Carcinoma, Lentigo Maligna, Lentigo Maligna Melanoma, Recurrence, Recurrent Disease, Skin Cancer
Conditions
Keywords
Clinical presentation, Outcomes, Mohs micrographic surgery, Slow Mohs, Micrographic surgery
Brief summary
Mohs micro-graphic surgery (Mohs) is a tissue-sparing, surgical treatment for different types of skin cancer (e.g. basal cell carcinoma, squamous cell carcinoma, lentigo maligna (melanoma). It is a procedure performed with frozen sections. Slow Mohs, a variant of micro-graphic surgery, is performed by formalin fixation and paraffin-embedded sections. Both in Mohs and Slow Mohs tumor margins are assessed to achieve complete removal. This study aims to investigate the clinical presentation and outcomes (i.e. complications and recurrence rates) in patients treated with Mohs or Slow Mohs in the dermatology department of the Maastricht University Medical Center+ in Maastricht, the Netherlands.
Interventions
PROCEDUREMohs surgery
Treatment of a skin disease by Mohs micrographic surgery technique (frozen sections).
PROCEDURESlow Mohs surgery
Treatment of a skin disease by Slow Mohs technique (formalin fixation and paraffin-embedded sections).
Sponsors
Maastricht University Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with a cutaneous lesion with an indication for Mohs micrographic surgery or Slow Mohs * patients who received a treatment with either Mohs or Slow Mohs between 1 july 2017 and 1 july 2023 at the dermatology department of the Maastricht University Medical Center+.
Exclusion criteria
* None.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of complications | Within 1 month after completion of the surgical intervention. | The incidence of complications after Mohs and Slow Mohs, expressed as absolute numbers and percentages. |
| Incidence of recurrence | Up to 5 year after completion of the surgical intervention. | The incidence of complications after Mohs and Slow Mohs, expressed as absolute numbers and percentages. Recurrence is defined as disease relapse after completion of treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hazard ratio of predisposing factors for complications | Within 1 month after completion of the surgical intervention. | Predisposing factors (patient- and tumor characteristics) for complications after Mohs and Slow Mohs, expressed in Hazard Ratio's and 95% confidence intervals. It is not possible to define the predisposing factors in advance, because this is currently unknown. We hypothesize the presence of diabetes, tobacco use and medication use to be predisposing factors for complications. |
| Hazard ratio of predisposing factors for recurrence | Up to 5 year after completion of the surgical intervention. | Predisposing factors (patient- and tumor characteristics) for recurrences after Mohs and Slow Mohs, expressed in Hazard Ratio's and 95% confidence intervals. It is not possible to define the predisposing factors in advance, because this is currently unknown. We hypothesize incomplete treatment, worse prognostic tumor factors (Stage III of IV, presence of perineural invasion or lymphovascular invasion) to be predisposing factors for recurrence. |
Countries
Netherlands
Outcome results
None listed