Comparison Of Efficacy Of Combination Of TAM Formula Vs Kligman Formula For Melasma.

Comparison Of The Efficacy Of Combination Of TAM Formula Versus Kligman Formula For Melasma At Tertiary Care Hospital,Karachi.

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06013540

Enrollment

122

Registered

2023-08-28

Start date

2022-08-01

Completion date

2023-08-30

Last updated

2023-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma

Brief summary

This study would offer the participants about the knowledge of these formula in the treatment of melasma and help the investigators in incorporating and updating the management protocols in medical practice.

Interventions

COMBINATION_PRODUCTTAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C)

TAM formula (hydroquinone 2%, tretinoin 0.05% and 5% vitamin C)

COMBINATION_PRODUCTKligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%)

Kligman formula (hydroquinone 4%, fluocinolone acetonide 0.01% and tretinoin 0.05%)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

25 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients between 25-65 years of age, either gender having melasma for over one month will be included in the study *

Exclusion criteria

* Pregnancy, breastfeeding, taking birth control pills or plans to become pregnant during the study * History of cutaneous photosensitization, porphyria, and hypersensitivity to porphyrins or photodermatosis * History of skin pathology or condition that could interfere with the evaluation or requires the use of interfering topical or systemic therapy * History of uncorrected coagulation defect or is currently using anti-coagulation medication (including but not limited to heavy aspirin therapy) * History of sensitivity to hydroquinone or Retin-A * History of evidence of a compromised immune system or hepatitis

Design outcomes

Primary

Measure	Time frame	Description
EFFICACY OF COMBINATION OF TAM FORMULA VERSUS KLIGMAN FORMULA IN TREATMENT OF MELASMA	Efficacy will be assesed upto 2 months.	Efficacy will be assessed by using Modified MASI(Melasma Area and Severity Index)In MASI scoring the area of involvement is calculated from 0 to 6 while the intensity and homogeneity of pigmentation are scored from 0 to 4 only. (Melasma Area Severity Index)

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026