Critical Illness, Frailty
Conditions
Keywords
clinical frailty scale, mechanical ventilation, elderly, EQ-5D-5L
Brief summary
The primary aim is to study change of critical frailty scale (CFS) and health related quality of life (EQ-5D-5L) in a long-term follow-up of ICU survivors. We aim to identify important ICU related predictors for change in CFS and EQ-5D-5L in long term follow up (1 yr). Secondary aim is to investigate how CFS pre-admission is related to intrahospital treatment intensity level, severity score and mortality.
Detailed description
This is a multi-centre norwegian observational, prospective multicenter Norway coordinated from University hospital North Norway, Tromso. The study is approved by The Regional Committee for Medical Research Ethics Northern Norway. The following scores will be assessed by asking the patient and relative during ICU stay: CFS, EQ5DL before current critical illness. The following demographic and clinical data will be retrieved from the medical records: Comorbidity before critical illness, reasons for ICU admission, daily severity score (SOFA- score), length of mechanical ventilation, dialysis, tracheostomy, Habitat before and after ICU treatment, ICU and hospital length of stay, complications retrieved during intensive care treatment, mortality, limitation of treatment. The patients will be followed up with telephone interview after hospital discharge for evaluation of: Comorbidity, CFS, EQ5DData for all sites are collected and managed using RedCap electronic data capture tools. Three research nurses will do the follow up with telephone interviews on all sites and record the data in RedCap. We aim to enroll 300 patients before 31. Des 2024.
Interventions
None listed
Sponsors
The Royal Norwegian Ministry of Health
Haukeland University Hospital
University Hospital, Akershus
Trondheim University Hospital
Bodø Hospital
University Hospital of North Norway
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>= 65 years * ≥ 24 hours mechanical ventilation * Written informed consent from patient or next of kin
Exclusion criteria
* Readmission of patient included in the study * Not possible to obtain a valid CFS or and EQ-5D-5L at admission or follow-up of CFS because of social context or language.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Clinical frailty score | Change in Clinical Frailty score from 3 months to 12 months follow up | Score from 1 to 9. |
| EuroQol 5-Dimension 5-Level (EQ-5D-5L) | Change in EQ-5D-5L from 3 months to 12 months | The scale measures quality of life on a 5-component scale |
| Mortality | ICU-stay or subsequent 12 months. | Mortality during ICU-stay or subsequent 12 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ICU readmission | Long-term follow up (1 yr) | ICU readmission rate |
| ICU-LOS | Through total ICU stay, up to 3 months | ICU length of stay |
| Treatment intensity level | From inclusion in the study to discharge from intensive care unit, up to three months. | ICU treatment intensity level |
Countries
Norway
Contacts
Primary ContactBjørn A Kroken, MD
Backup ContactShirin K Frisvold, MD/PhD
Outcome results
None listed