Central Nervous System Tuberculosis
Conditions
Brief summary
This is a retrospective clinical study to analyze the clinical characteristics, complications, and effects of different treatment options on long-term prognosis in patients with central nervous system tuberculosis. All cases of central nervous system tuberculosis diagnosed between 2016 and 2021 were included in the electronic medical record system of one center, and data such as demographics, hospitalization information, clinical information, laboratory or imaging examinations, treatment plans, and outcomes were collected.
Interventions
None listed
Sponsors
Tongji Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* The patient meets the following criteria 1) or 2) or 3): 1. The discharge diagnosis is central nervous system tuberculosis, refer to the ICD-10 code related to central nervous system tuberculosis. 2. The discharge diagnosis was tuberculous meningitis (ICD-10: A17.000), or tuberculous cerebrospinal meningitis (ICD-10: A17.001), or tuberculous meningoencephalitis (ICD-10: A17.803 ), or tuberculous encephalitis (ICD-10: A17.804), or tuberculous brain abscess (ICD-10: A17.805), or spinal tuberculosis (ICD-10: A17.806), or tuberculous encephalitis Water (ICD-10: A17.807). 3. Tuberculous meningitis diagnosed according to the Guidelines for Diagnosis and Treatment of Central Nervous System Tuberculosis in China (2019 Edition) * Age and gender are not limited.
Exclusion criteria
* Patients with no clear diagnosis at discharge. * Patients judged by the investigator to be unsuitable for inclusion in this protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 2-year survival rate | 1 years,2 years | Calculate the 1-year survival rate and 2-year survival rate. |
| 2-year disability rate | 1 years,2 years | Calculate the 1-year disability rate and 2-year disability rate. Common disabilities include aphasia, hemiplegia, paraplegia, deafness, blindness, mental retardation, etc. For reference, please refer to the 《Grading of Human Injury and Disability Degree》 and 《Guidance for determination of cause-and-effect relationship between personal injury and disease》. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of complications in patients with different treatment regimens | 2 years | The electronic medical record system was used to collect patients' complications from baseline (admission) to 24 months, and the incidence of complications of different treatment options was compared. |
| Clinical features: age of onset, mode of onset | 2 years | age of onset, mode of onset |
| proportion of patients admitted to ICU | 2 years | — |
| length of hospital stay | 2 years | — |
| The presense of clinical symptoms of patients | 2 years | The number and severity of clinical symptoms of patients. |
Countries
China
Outcome results
None listed