Light and Sleep Fragmentation

Application of Precision Medicine to Phototherapy: a Stepped Care Approach to Consolidate Sleep and Slow Cognitive Decline in Older Adults

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06009289

Enrollment

120

Registered

2023-08-24

Start date

2026-06-01

Completion date

2028-05-30

Last updated

2023-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment, Mood Disorders, Sleep

Brief summary

This trial will examine scheduled exposure to bright light in the morning and afternoon as a countermeasure to sleep fragmentation in older individuals with mild cognitive impairment.

Interventions

BEHAVIORALLight therapy

One hour of exposure to bright light, either by being outdoors or with a phototherapy lamp if indoor

Study design

Allocation

NON_RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

65 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

* Mild Cognitive Impairment * Age \>65

Exclusion criteria

* Severe depression * Unstable psychiatric or medical disease * Acute infection

Design outcomes

Primary

Measure	Time frame	Description
Sleep fragmentation	4 weeks	24 hour sleep wake patterns will be quantitated with a non-parametric measure, intradaily variation

Secondary

Measure	Time frame	Description
Cognition	6 months	Performance on the WAIS-4
Mood	6 months	Geriatric Depression Scale, range: 0-15 with higher scores being associated with greater depressive symptomatology

Countries

United States

Contacts

Primary ContactRenske Lok, PhD

rlok@stanford.edu

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026