Cerebral Edema, Coagulation and Hemorrhagic Disorders, Inflammation
Conditions
Brief summary
Explore the role of Inflammation and coagulation factors in cerebrospinal fluid for predicting persistent cerebral edema after subarachnoid hemorrhage
Interventions
DIAGNOSTIC_TESTInflammatory factors and coagulation factors level in cerebrospinal fluid after subarachnoid hemorrhage
Inflammatory factors and coagulation factors level in cerebrospinal fluid will be tested by ELISA kits.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Subarachnoid hemorrhage patients admitted to our neurosurgery department with modified Fisher Scale 3-4, with a confirmed radiographic diagnosis.
Exclusion criteria
* Angiogram-negative patients, patients with a history of trauma or previous brain injury (stroke, hemorrhage, surgery et al. which left associated chronic changes on CT), arteriovenous malformation, radiological data lost, accompany with serious comorbidities before subarachnoid hemorrhage onset (such as coagulation defects, uncontrollable hypertension, and arrhythmia et.al.), initial radiological data performed more than 3 days after SAH onset
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral edema after subarachnoid hemorrhage | At 3 and 7days after SAH onset | Cerebral edema after subarachnoid hemorrhage will be determined by the SEBES score. SEBES 0-2 is mild edema; SEBES 3-4 is severe edema. |
| Outcome at 3 months after subarachnoid hemorrhage | 3 months after subarachnoid hemorrhage | Outcome will be determined by the modified Rankin Score (mRS). mRS 0-2 is favorable outcome; mRS3-5 is poor outcome. |
Countries
China
Contacts
Primary ContactYuanjian Fang, M.D
Backup ContactSheng Chen, M.D
Outcome results
None listed