Dyslipidemias
Conditions
Keywords
Dyslipidemia, Calisthenic Exercise, Exercise Capacity
Brief summary
Dyslipidemia is expressed as the serum concentration of lipid molecules with different structures outside the normal level. Deviation of serum lipid level from normal is accepted as the primary or most important factor in various cardiac and metabolic diseases, especially atherosclerosis. Dyslipidemia-related cardiovascular structure change is accepted as an important public health problem worldwide, and it is stated that the combined use of medical treatment, changes in diet and physical activity/structured exercise programs in the treatment of dyslipidemia is important in the success of treatment.
Detailed description
Lipid profile disorders (especially high total blood cholesterol level) are a major problem worldwide, and accepted as a important public health problem. It has been reported that approximately one out of every three people worldwide has been exposed to dyslipidemia risk factors. Prevalence studies showed that lipid profile disorders vary between 6.9% and 43.6% worldwide. Today, ischemic heart and central nervous system diseases are the most important causes of mortality and morbidity in adult population, globally. Especially, it is accepted that lipid profile disorders are the leading risk factors causing ischemic heart diseases. Prevalence varies according to regions, lifestyle habits and individual factors, because of lipid profile disorders are caused by many different genetic and environmental factors. Apart from individual factors, there are other factors that lipid weight in diet, nutrient deficiencies which balancing lipid metabolism, physical activity level and inactivity, other comorbid diseases, and medical treatments change lipid metabolism in individuals and lead to deterioration in lipid profile. Especially lifestyle habits affect lipid metabolism most easily and they are the most easily modifiable factors. It is recommended to apply a multi-dimensional approach when treating lipid profile disorders. It is recommended that, to include diet counseling and exercise therapy in these approaches. Exercise therapy is especially recognized as an important treatment option for the control and treatment of obesity, hypertension, hyperglycemia and metabolic syndrome symptoms that may accompany dyslipidemia. It has been reported that aerobic exercise programs increase patients' quality of life and functionality which applied to dyslipidemia patients, but there is lack of information available in literature about the effects of calisthenic exercises in patients with dyslipidemia.
Interventions
Exercises for upper extremity, lower extremity and trunk which applying just patient's own body weight via using body mechanics. There is no need for any tools for exercises.
OTHERAerobic Exercises
Exercises which loading cardiovascular, respiratory and muscular system at the same time. Treadmill training will apply in the study.
Sponsors
Hacettepe University
Çankırı Karatekin University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Masking description
Patients and his/her caregivers will allocate in study via computer based randomisation, and will not know about his/her and also other participants group in study.
Intervention model description
Experimental model of study consist from three arm. * First Arm: Patients will take aerobic exercise training in 3 days per week, and 7 days per week calisthenic exercises for upper extremity, lower extremity and trunk, for 8 weeks. * Second Arm: Patients will take aerobic exercise training in 3 days per week, for 8 weeks. * Third Arm: Patients will take physical activity recommendations, and just screening after 8 weeks.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Screening by the internal medicine clinic with the diagnosis of dyslipidemia * Being between 18 to 65 years old * Volunteering to participate in the research
Exclusion criteria
* Having any cardiac disease * Having a co-existing psychiatric illness (like schizophrenia, bipolar disorder, etc.) * Being infected with COVID-19 in the last 3 months * Having any neurological problems that may affect cooperation * Having pulmonary or orthopedic problem that may affect functional capacity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exercise Capacity | Second Day | Cardiopulmonary exercise capacity will assess as primary outcome measure, via cardiopulmonary exercise test (CPET). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sit-to-Stand Test | First Day | A one-minute sit-to-stand test will be applied to the patients. One standing position followed by sitting will count as one cycle. Patients' total cycles within 60 seconds will be counted as test score (in cycle/minute units of measure) |
| Blood Lipids Concentration Assessment | First Day | Concentration of LDL-C, HDL-C, Total cholesterol (TC) and Triglyceride (TG) will assess in blood (in mg/dL units of measure) after 12 hours fasting. |
| Apolipoprotein A1 Concentration Assessment | First Day | Concentration of Apolipoprotein A1 will assess in blood (in g/dL units of measure) after 12 hours fasting. |
| Blood Sugar Concentration Assessment | First Day | Concentration of fasting blood sugar (in mmol/L units of measure) and rate of HbA1c (in % units of measure) will assess in blood after 12 hours fasting. |
| Timed Up-and-Go Test | First Day | Timed up-and-go test will be applied to the patients. Patients will be asked to get up from the chair, walk the 3-meter distance, return and sit back in the chair, as quickly as possible. The total time that patients complete the test and sit on the chair again will be recorded as the test score (in second/lap units of measure). |
| Peripheral Muscle Strength Assessment | First Day | The muscle strength of the shoulder abductor and knee extensor muscles on the dominant and non-dominant sides of the patients will be evaluated with a portable dynamometer. During the evaluations, the patients will be asked to try to resist the force to be applied in the opposite direction of the relevant muscle's function with isometric muscle contraction. The force released during the test will be measured and the highest score (in newton \[N\] units of measure) will be recorded for each muscle within 3 tests. |
| Hand-Grip Strength Assessment | First Day | The hand grip strength of the patients will be measured with a portable hand dynamometer. The patients will be asked to grasp the dynamometer with their fingers on the dominant and non-dominant side and squeeze it most strongly. The highest score (in kilogram force \[KgF\] units of measure) of 3 measurements on both sides will be recorded. |
| Flexibility Assessment | First Day | Flexibility of patients will be evaluated with sit-and-reach test. Patients will be asked to stretch their hands on a bench with a measuring ruler while in a long sitting position with the ankle angled at 90 degrees and the knee fully extended. How many centimeters ahead or behind the toes of the patient's fingertips will be measured. |
| C-reactive Protein Concentration Assessment | First Day | Concentration of C-reactive protein (in mg/dL units of measure) will assess in blood after 12 hours fasting. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Quality of Life Assessment | Second Day | Quality of life will assess via Short Form-36 Quality of Life Questionnaire. The questionnaire consist from 36 questions and total score ranges between 0 to 100 point. Higher scores shows better quality of life. |
Countries
Turkey (Türkiye)
Outcome results
None listed