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Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery

Optimizing Postoperative Pain Control After Laparoscopic Colorectal Surgery by Supplementing Ultrasound-guided Erector Spinae Plane Block With Ketamine or Transdermal Fentanyl Patch

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06007378
Enrollment
120
Registered
2023-08-23
Start date
2023-09-05
Completion date
2025-07-22
Last updated
2026-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Brief summary

Erector spinae plane block (ESPB) is a novel regional block technique that was proven to have superior outcomes in relieving postoperative pain in colorectal surgeries.Ketamine enhances the impact of local anaesthetics by reducing the duration and extent of motor block while shortening the onset of sensory and motor block.Transdermal Fentanyl Patch (TFP) was better than transdermal buprenorphine in postoperative analgesia following abdominal surgeries.

Interventions

OTHERBupivacaine and ketamine

Bilateral erector spinae plane block (bupivacaine and ketamine)

OTHERBupivacaine and transdermal fentanyl patch

Bilateral erector spinae plane block (bupivacaine) and transdermal fentanyl patch

OTHERBupivacain

Bilateral erector spinae plane block (bupivacaine)

Sponsors

Ain Shams University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patients undergoing laparoscopic colorectal surgery. * American Society of Anesthesiologists (ASA) physical status I or II.

Exclusion criteria

* Known allergy to one of the study medications. * Skin infections at the site of the needle puncture. * Hepatic, renal or cardiac dysfunction. * Patients diagnosed with obstructive sleep apnoea

Design outcomes

Primary

MeasureTime frameDescription
The time to first rescue analgesia after surgery (hour)The first 48 hours after surgeryThe time to first rescue analgesia after surgery (hour)

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 19, 2026