Acute Heart Failure, Biomarker, Chronic Kidney Diseases
Conditions
Brief summary
Acute heart failure (AHF) is defined as new or worsening of symptoms and signs of heart failure and is the most frequent cause of unplanned hospital admission in elderly patients. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is one of the most developed prognostic markers for AHR patients and. NT-pro-BNP has limitations in terms of diagnostic or predictive accuracy in patients with chronic kidney disease (CKD). Plasma proteomics have the potential to examine underlying pathophysiological and prognostic roles, so we compared the plasma proteomic signature to predict outcomes of patients with or without CKD hospitalized for AHF.
Interventions
None listed
Sponsors
Cheng-Hsin General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* hospitalized for acute heart failure
Exclusion criteria
* initial serum NT-proBNP level \<300ng/ml, pregnancy, amputated, and end-stage renal disease under regular dialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| major adverse cardiovascular events | 1 year | mortality, acute myocardial infarction, acute stroke, and heart failure hospitalization |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| major adverse kidney events | 1 year | mortality, new end-stage renal disease, and 30% decline in estimated GFR |
Countries
Taiwan
Contacts
Primary ContactShang Feng Yang, MD
Outcome results
None listed