Acute Heart Failure, Acute Myocardial Infarction, Cardiogenic Shock, Microbial Colonization, Out-Of-Hospital Cardiac Arrest
Conditions
Brief summary
Cardiogenic shock is associated with a high mortality. The microbiome is a double-edged sword which can convey protective and detrimental cardiovascular effects. The significance of the enteral micobiome on cardiovascular mortality of patients with cardiogenic shock is still not known. This study aims to provide a deeper understanding of the role of the enteral microbiome and microbiome dependent metabolites in mortality and disease progression of patients with cardiogenic shock.
Interventions
OTHERObservational study
No intervention: observational study
Sponsors
University Hospital, Essen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \>18y * signs of cardiogenic shock regardless of etiology * lactate \>3mmol/L * and signs of organ dysfunction (urine output \<30 ml/h, cold extremities, altered mental status) * and systolic blood pressure \<90 mmHg for \>30 minutes or need for vasopressor therapy
Exclusion criteria
* pregnancy/lactation period * antibiotic treatment within \>24h * chronic inflammatory bowel disease * short bowel syndrome * artificial bowel outlet * persistent diarrhea or vomiting in the past 3 months * simultaneous participation in another interfering nutrition study * active chemo or radiation therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between enteral microbiome composition and mortality | Sampling will be performed within 24 hours of onset of cardiogenic shock and clinical evaluation will be performed after 1 month | Stool samples are collected and clinical evaluation will be performed at below mentioned time points |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between TMAO serum level and mortality | Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3 | Blood samples are collected at below mentioned time points |
| Correlation between SCFA serum level and mortality | Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3 | Blood samples are collected at below mentioned time points |
| Correlation between inflammatory profile (CRP, PCT, Interleukin panel) and mortality | Sampling will be performed within 24 hours of onset of cardiogenic shock and on day 3 | Blood samples are collected at below mentioned time points |
Countries
Germany
Outcome results
None listed