Bipolar Disorder
Conditions
Keywords
Lithium, Lamotrigerne, Valproate, Physical disorders
Brief summary
Nationwide population-based register linkage study covering the entire 5.9 million inhabitants in Denmark systematically investigating the associations between sustained long-term use of lithium versus lamotrigine and valproate, and the risk of a range of physical disorders emulating a randomized trial.
Detailed description
The study includes two cohorts. Cohort 1: all 12.607 patients with a diagnosis of bipolar disorder (ICD-10 code: DF30-31.9) who subsequently were exposed to either lithium, lamotrigine or valproate between 1997 and 2021. Cohort 2: as Cohort 1, but regardless of prior diagnosis of bipolar disorder (N= 156.678). Main analyses considered a patient exposed to a drug 92 days after a prescription and a 10-year follow-up and 4 sensitivity analyses considered a patient exposed to a drug for 60 and 180 days after a prescription, respectively, and with 5- and 15-years follow-up, respectively.
Interventions
DRUGLithium
Sustained long-term exposure
Sponsors
Mental Health Services in the Capital Region, Denmark
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of bipolar disorder and subsequent exposure to either lithium, lamotrigine or valproate
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incident stroke (separately for intracerebral hemorrhage and cerebral infarction) | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Arteriosclerosis | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Angina pectoris | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Myocardial infarction | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Diabetes mellitus (separately for type 1 diabetes and type 2 diabetes) | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Myxoedema | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Osteoporosis | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Dementia (separately for Alzheimer's disease and other dementia) | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Parkinson's disease | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
| Chronic kidney disease (definite chronic kidney disease and possible Chronic kidney disease) | 1997 to 2021 | Diagnosis in the Danish National Hospital Register |
Countries
Denmark
Outcome results
None listed