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Personality Change Study for Borderline Personality Disorder

Engaging Higher-Order Mechanisms of Psychopathology: A Parsimonious Approach to Precision Medicine

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06005129
Enrollment
39
Registered
2023-08-22
Start date
2024-09-15
Completion date
2026-06-02
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Borderline Personality Disorder

Brief summary

Participants with borderline personality disorder will undergo an a 2 - 4 week baseline assessment to determine level of outcomes of interest in the absence of treatment. After the baseline period, participants will receive six weekly 50-60-minute treatment sessions. After the 6 treatment sessions, participants will complete a 4-week follow-up period to determine the sustainability of the treatment module.

Interventions

BEHAVIORALPersonality-Based Therapy

Participants will be randomized to a 2- or 4-week assessment-only baseline period. After the baseline period, participants will receive the personality-based treatment module corresponding to their highest clinical elevation (i.e., neuroticism, \[low\] conscientiousness, \[low\] agreeableness). Treatment will consist of six weekly 50-60-minute sessions. After the 6-week intervention period, participants will complete a 4-week follow-up period to determine the sustainability of effects observed

Sponsors

Shannon E. Sauer-Zavala
Lead SponsorOTHER
American Psychological Foundation
CollaboratorOTHER
National Institute of Mental Health (NIMH)
CollaboratorNIH

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Speak English fluently * Diagnosis of Borderline Personality Disorder

Exclusion criteria

* diagnosed psychological conditions that would be better addressed by alternative treatments * concurrent psychotherapy * medication instability * substance use disorder

Design outcomes

Primary

MeasureTime frameDescription
Change in clinician-rated borderline personality disorder symptomsup to 14 weeks (pre-baseline, pre-intervention, post-intervention, post-follow-up)Change in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - clinician-rated version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms
Change in patient-reported borderline personality disorder symptomsweekly up to 14 weeksChange in borderline personality disorder symptoms will be measured using Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) - self-report version. Scores range from 0-36; higher scores indicate greater severity of borderline personality disorder symptoms

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORShannon Sauer-Zavala, PhD

University of Kentucky

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 14, 2026